2-(trimethylsilyl)ethyl 4-{4-[(tert-butoxycarbonyl) (methyl)amino]phenyl}isoquinoline-6-carboxylate

Base Information

Chemical Name:2-(trimethylsilyl)ethyl 4-{4-[(tert-butoxycarbonyl) (methyl)amino]phenyl}isoquinoline-6-carboxylate
CAS No.:1248555-83-0
Molecular Formula:C₂₇H₃₄N₂O₄Si
Molecular Weight:478.663
Hs Code.:

Synonyms:2-(trimethylsilyl)ethyl 4-{4-[(tert-butoxycarbonyl) (methyl)amino]phenyl}isoquinoline-6-carboxylate

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Chemical Property of 2-(trimethylsilyl)ethyl 4-{4-[(tert-butoxycarbonyl) (methyl)amino]phenyl}isoquinoline-6-carboxylate

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Technology Process of 2-(trimethylsilyl)ethyl 4-{4-[(tert-butoxycarbonyl) (methyl)amino]phenyl}isoquinoline-6-carboxylate

There total 1 articles about 2-(trimethylsilyl)ethyl 4-{4-[(tert-butoxycarbonyl) (methyl)amino]phenyl}isoquinoline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 916587-44-5
methyl-(4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)pnenyl)-carbamic acid tert-butyl ester

: 1235382-38-3
2-(trimethylsilyl)ethyl 4-{[(trifluoromethyl)sulfonyl]oxy}isoquinoline-6-carboxylate

: 1248555-83-0
2-(trimethylsilyl)ethyl 4-{4-[(tert-butoxycarbonyl) (methyl)amino]phenyl}isoquinoline-6-carboxylate

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 90 ℃; for 1h; Inert atmosphere;

Reference yield: 51.0%

: 1248555-83-0
2-(trimethylsilyl)ethyl 4-{4-[(tert-butoxycarbonyl) (methyl)amino]phenyl}isoquinoline-6-carboxylate

: 1248555-85-2
Tert-butyl [4-(6-carbamoylisoquinolin-4-yl)phenyl]methylcarbamate

Guidance literature:: 2-(trimethylsilyl)ethyl 4-{4-[(tert-butoxycarbonyl) (methyl)amino]phenyl}isoquinoline-6-carboxylate; With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 2h; Inert atmosphere;

With ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

: 1248555-83-0
2-(trimethylsilyl)ethyl 4-{4-[(tert-butoxycarbonyl) (methyl)amino]phenyl}isoquinoline-6-carboxylate

: 1248553-88-9
4-{4-[formyl (methyl) amino]phenyl}isoquinoline-6-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / Inert atmosphere

1.2: 4 h / 20 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

2.2: 0 °C

3.1: acetic acid / 4 h / 0 - 20 °C / Inert atmosphere

With tetrabutyl ammonium fluoride; acetic acid; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;