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Usage

Uses

Used in Organic Synthesis:
Methyl-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-carbamic acid tert-butyl ester is used as a reagent in organic reactions for its ability to facilitate the formation of complex organic molecules. Its high reactivity and stability make it an indispensable tool in the synthesis of various compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, Methyl-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-carbamic acid tert-butyl ester is used as a precursor for the synthesis of pharmaceuticals. Its role in the development of new drugs is significant, as it can be incorporated into the molecular structures of potential therapeutic agents.
Used in Agrochemical Industry:
Methyl-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-carbamic acid tert-butyl ester is also utilized in the agrochemical industry as a precursor for the synthesis of agrochemicals. Its contribution to the development of pesticides and other agricultural chemicals is vital for enhancing crop protection and yield.
Used in Material Science:
In the field of material science, Methyl-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-carbamic acid tert-butyl ester is employed as a component in the synthesis of advanced materials. Its unique properties allow it to be integrated into the development of new materials with specific characteristics for various applications.

Upstream product

• 60144-53-8 N-(tert-butoxycarbonyl)-4-fluoroaniline 
• 662112-08-5 phenyl 4-(methylamino)benzoate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 73183-34-3 bis(pinacol)diborane 
• 330793-01-6 (4-tert-butoxycarbonylaminophenyl)boronic acid pinacol ester 
• 74-88-4 methyl iodide 
• 60577-34-6 p-iodo-N-methylaniline 
• 306768-12-7 (4-iodophenyl)-methyl-carbamic acid tert-butyl ester 

Downstream Products

• 1577233-12-5 tert-butyl (4-(difluoromethyl)phenyl)(methyl)carbamate 
• 1374109-11-1 C₃₀H₄₁FN₂O₄Si 
• 1374108-86-7 C₃₈H₄₀N₂O₅ 
• 1374109-01-9 C₂₅H₃₀N₂O₄ 
• 1374108-67-4 C₃₁H₃₃FN₂O₄ 
• 1248555-87-4 4-[4-(methylamino)phenyl]isoquinoline-6-carboxamide 
• 1248555-85-2 Tert-butyl [4-(6-carbamoylisoquinolin-4-yl)phenyl]methylcarbamate 
• 1248553-88-9 4-{4-[formyl (methyl) amino]phenyl}isoquinoline-6-carboxamide 
• 1248555-83-0 2-(trimethylsilyl)ethyl 4-{4-[(tert-butoxycarbonyl) (methyl)amino]phenyl}isoquinoline-6-carboxylate 
• 1246093-98-0 tert-butyl methyl(4-(4-nitroquinolin-2-yl)phenyl)carbamate 
• 1246094-00-7 tert-butyl (4-(isoquinolin-3-yl)phenyl)(methyl)carbamate 
• 1246093-99-1 tert-butyl methyl(4-(quinolin-3-yl)phenyl)carbamate 
• 1062175-05-6 methyl-[4-(4-morpholin-4-yl-1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)-phenyl]-carbamic acid tert-butyl ester 
• 1014613-23-0 1,1-dimethylethyl methyl-{4-[2-methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]phenyl}carbamate 

Relevant academic research and scientific papers

Functional Group Interconversion: Decarbonylative Borylation of Esters for the Synthesis of Organoboronates

A new and efficient nickel-catalyzed decarbonylative borylation reaction of carboxylic acid esters with bis(pinacolato)-diboron has been developed. This transformation allows access to structurally diverse aryl as well as alkenyl and alkyl boronate esters with high reactivity, broad substrate scope, and excellent functional-group tolerance. Further experiments show that this protocol can be carried out on a gram scale and applied to orthogonal synthetic strategies.

Rhodium-Catalyzed ipso-Borylation of Alkylthioarenes via C-S Bond Cleavage

Rhodium-catalyzed transformation of alkyl aryl sulfides into arylboronic acid pinacol esters via C-S bond cleavage is reported. In combination with transition-metal-catalyzed sulfanyl group-guided regioselective C-H borylation reactions of alkylthioarenes, this method allows the synthesis of a diverse range of multisubstituted arenes.

Ni/Cu-Catalyzed Defluoroborylation of Fluoroarenes for Diverse C-F Bond Functionalizations

Ni/Cu-catalyzed transformation of fluoroarenes to arylboronic acid pinacol esters via C-F bond cleavage has been achieved. Further versatile derivatization of an arylboronic ester has allowed for the facile two-step conversion of a fluoroarene to diverse functionalized arenes, demonstrating the synthetic utility of the method.

SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS

Provided are pyridopyrazine compounds of formula (1), pharmaceutical compositions thereof and methods of use therefore, wherein R1, R2, R3, R4 and m are as defined in the specification.

NOVEL HYDROXAMIC ACID DERIVATIVE

Provided is a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria. Provided is a hydroxamic acid derivative represented by the following general formula [1] or a pharmaceutically acceptable salt thereof:

SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS

Provided are certain pyridopyrazine compounds, pharmaceutical compositions thereof and methods of use therefor.

Computer-guided design of a Cu(II) receptor and sensor

The computer program CAVEAT was used to design a linker structure to connect four imidazole 4-carboxamide groups in a distorted square planar arrangement optimal for binding Cu(ii) ions. The resulting macrocyclic structure was prepared by the synthesis of