N₂-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenyl)-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenyl)-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)pyrimidine-2,4-diamine
• CAS No.: 1356493-38-3
• Molecular Formula: C₂₄H₃₁F₂N₉
• Molecular Weight: 483.567

Synonyms:N₂-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenyl)-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)pyrimidine-2,4-diamine

Chemical Property of N₂-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenyl)-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)pyrimidine-2,4-diamine

Chemical Property:

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Technology Process of N₂-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenyl)-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)pyrimidine-2,4-diamine

There total 5 articles about N₂-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenyl)-5-fluoro-N₄-(1,2,2,6,6-pentamethylpiperidin-4-yl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-amino-1,2,2,6,6-pentamethylpiperidine (40327-96-6) → N2-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenyl)-5-fluoro-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)pyrimidine-2,4-diamine (1356493-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / 20 °C

2.1: toluene-4-sulfonic acid / isopropyl alcohol / 100 °C

2.2: 20 °C

With toluene-4-sulfonic acid; In methanol; isopropyl alcohol;

Reference yield:

2-bromo-4-fluoroaniline (1003-98-1) → N2-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenyl)-5-fluoro-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)pyrimidine-2,4-diamine (1356493-38-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sulfuric acid / ethyl acetate / -30 - -20 °C

1.2: 1.08 h / -20 - -15 °C

2.1: tricyclohexylphosphine; caesium carbonate / palladium diacetate / toluene; water / 100 °C / Inert atmosphere

3.1: trimethylsilylazide; acetic acid / 70 °C

3.2: pH 12 - 14

4.1: hydrogen / palladium 10% on activated carbon / ethanol; water; acetic acid / 1551.49 Torr

5.1: toluene-4-sulfonic acid / isopropyl alcohol / 100 °C

5.2: 20 °C

With trimethylsilylazide; sulfuric acid; hydrogen; caesium carbonate; toluene-4-sulfonic acid; acetic acid; tricyclohexylphosphine; palladium 10% on activated carbon; palladium diacetate; In ethanol; water; acetic acid; ethyl acetate; isopropyl alcohol; toluene;

Reference yield:

2-bromo-4-fluoro-5-nitrophenylamine (346433-97-4) → N2-(4-cyclopropyl-2-fluoro-5-(1H-tetrazol-1-yl)phenyl)-5-fluoro-N4-(1,2,2,6,6-pentamethylpiperidin-4-yl)pyrimidine-2,4-diamine (1356493-38-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tricyclohexylphosphine; caesium carbonate / palladium diacetate / toluene; water / 100 °C / Inert atmosphere

2.1: trimethylsilylazide; acetic acid / 70 °C

2.2: pH 12 - 14

3.1: hydrogen / palladium 10% on activated carbon / ethanol; water; acetic acid / 1551.49 Torr

4.1: toluene-4-sulfonic acid / isopropyl alcohol / 100 °C

4.2: 20 °C

With trimethylsilylazide; hydrogen; caesium carbonate; toluene-4-sulfonic acid; acetic acid; tricyclohexylphosphine; palladium 10% on activated carbon; palladium diacetate; In ethanol; water; acetic acid; isopropyl alcohol; toluene;

upstream raw materials:

2-bromo-4-fluoroaniline

4-amino-1,2,2,6,6-pentamethylpiperidine

2-bromo-4-fluoro-5-nitrophenylamine

2-Cyclopropyl-4-fluoro-5-nitroaniline

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