2-(2-{2-[2-(4-cyano-benzoylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-2-methyl-propionic acid

Base Information

• Chemical Name: 2-(2-{2-[2-(4-cyano-benzoylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-2-methyl-propionic acid
• CAS No.: 843612-94-2
• Molecular Formula: C₂₄H₃₃N₅O₆
• Molecular Weight: 487.556
• Mol file: 843612-94-2.mol

Synonyms:2-(2-{2-[2-(4-cyano-benzoylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-2-methyl-propionic acid

Chemical Property of 2-(2-{2-[2-(4-cyano-benzoylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-2-methyl-propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-{2-[2-(4-cyano-benzoylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-2-methyl-propionic acid

There total 4 articles about 2-(2-{2-[2-(4-cyano-benzoylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-2-methyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(2-{2-[2-(4-cyano-benzoylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-2-methyl-propionic acid tert-butyl ester (843612-90-8) → 2-(2-{2-[2-(4-cyano-benzoylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-2-methyl-propionic acid (843612-94-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/ja043607e

Reference yield:

Z-(Aib)4-OtBu (4512-38-3) → 2-(2-{2-[2-(4-cyano-benzoylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-2-methyl-propionic acid (843612-94-2)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd / methanol

2: 53 percent / 7-aza-1-hydroxy-1,2,3-benzotriazole; EDC*HCl; N,N-diisopropylethylamine / CH₂Cl₂ / 72 h / 20 °C

3: 92 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium; In methanol; dichloromethane;

DOI:10.1021/ja043607e

Reference yield:

4-cyanobenzoic Acid (619-65-8,333406-09-0) → 2-(2-{2-[2-(4-cyano-benzoylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-2-methyl-propionic acid (843612-94-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / 7-aza-1-hydroxy-1,2,3-benzotriazole; EDC*HCl; N,N-diisopropylethylamine / CH₂Cl₂ / 72 h / 20 °C

2: 92 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/ja043607e

upstream raw materials:

2-(2-{2-[2-(4-cyano-benzoylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-2-methyl-propionic acid tert-butyl ester

4-cyanobenzoic Acid

Z-(Aib)4-OtBu

H-(Aib)4-O-t-Bu