Z-(Aib)4-OtBu

Base Information

• Chemical Name: Z-(Aib)4-OtBu
• CAS No.: 4512-38-3
• Molecular Formula: C₂₈H₄₄N₄O₇
• Molecular Weight: 548.68
• Mol file: 4512-38-3.mol

Synonyms:Z-(Aib)4-OtBu

Chemical Property of Z-(Aib)4-OtBu

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-(Aib)4-OtBu

There total 7 articles about Z-(Aib)4-OtBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester (83537-94-4) → Z-(Aib)4-OtBu (4512-38-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; 5%-palladium/activated carbon / methanol / 20 °C

2: acetonitrile / 24 h / Reflux

With 5%-palladium/activated carbon; hydrogen; In methanol; acetonitrile;

DOI:10.1039/c3cc44713h

Reference yield:

Z-Aib-OBt (154561-22-5) → Z-(Aib)4-OtBu (4512-38-3)

Guidance literature:

Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 72 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

4: acetonitrile / 24 h / Reflux

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;

DOI:10.1039/c3cc44713h

Reference yield:

Z-Aib-OH (15030-72-5) → Z-(Aib)4-OtBu (4512-38-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 0 °C

2: triethylamine / dichloromethane / 72 h / 20 °C

3: trifluoroacetic acid / dichloromethane / 6 h / 20 °C

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 20 °C

5: acetonitrile / 24 h / Reflux

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;

DOI:10.1039/c3cc44713h

upstream raw materials:

Benzyloxycarbonyl-α-aminoisobutyryl-α-aminoisobutyric acid tert butyl ester

Z-Aib-OBt

N-(Benzyloxycarbonyloxy)succinimide

Z-Aib-OH

Downstream raw materials:

Z-(Aib)4-NHtBu

2-(2-{2-[2-(4-cyano-benzoylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-2-methyl-propionic acid

2-(2-{2-[2-(4-cyano-benzoylamino)-2-methyl-propionylamino]-2-methyl-propionylamino}-2-methyl-propionylamino)-2-methyl-propionic acid tert-butyl ester

N-[benzyloxycarbonyl]-2-methylalanyl-2-methylalanyl-2-methylalanyl-2-methylalanine