({(2-Amino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

Base Information

• Chemical Name: ({(2-Amino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester
• CAS No.: 202914-69-0
• Molecular Formula: C₂₆H₃₁N₆O₁₀P
• Molecular Weight: 618.54
• Mol file: 202914-69-0.mol

Synonyms:({(2-Amino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

Chemical Property of ({(2-Amino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ({(2-Amino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

There total 4 articles about ({(2-Amino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

({(2-tert-Butoxycarbonylamino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester (185670-79-5) → ({(2-Amino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester (202914-69-0)

Guidance literature:

With trifluoroacetic acid; at 0 - 10 ℃;

DOI:10.1002/anie.199728091

Reference yield:

thymidyl acetic acid (20924-05-4) → ({(2-Amino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester (202914-69-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / N-ethylmorpholine, HATU / dimethylformamide / 24 h / Ambient temperature

2: 100 percent / TFA / 0 - 10 °C

With N-ethylmorpholine;; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;

DOI:10.1002/anie.199728091

Reference yield:

bis(p-nitrophenylethyl)phosphite (85363-76-4) → ({(2-Amino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester (202914-69-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 23 percent / 2.5 h / 100 °C

2: 66 percent / N-ethylmorpholine, HATU / dimethylformamide / 24 h / Ambient temperature

3: 100 percent / TFA / 0 - 10 °C

With N-ethylmorpholine;; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;

DOI:10.1002/anie.199728091

upstream raw materials:

({(2-tert-Butoxycarbonylamino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

thymidyl acetic acid

bis(p-nitrophenylethyl)phosphite

[(2-tert-Butoxycarbonylamino-ethylamino)-methyl]-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

Downstream raw materials:

C₅₂H₅₇N₈O₁₄P

({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid mono-[2-(4-nitro-phenyl)-ethyl] ester

({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester