({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

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Chemical Name:({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester
CAS No.:202914-62-3
Molecular Formula:C₄₆H₄₇N₆O₁₁P
Molecular Weight:890.887
Hs Code.:

({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

Synonyms:({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

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Chemical Property of ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

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Technology Process of ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

There total 5 articles about ({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 202914-69-0
({(2-Amino-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

: 14470-28-1
mono-4-methoxytrityl chloride

: 202914-62-3
({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; at 0 - 5 ℃; for 12h;
DOI:10.1002/anie.199728091

Reference yield:

: 20924-05-4
thymidyl acetic acid

: 202914-62-3
({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / N-ethylmorpholine, HATU / dimethylformamide / 24 h / Ambient temperature

2: 100 percent / TFA / 0 - 10 °C

3: 100 percent / diisopropylethylamine / 12 h / 0 - 5 °C

With N-ethylmorpholine;; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1002/anie.199728091

Reference yield:

: 85363-76-4
bis(p-nitrophenylethyl)phosphite

: 202914-62-3
({(2-{[(4-Methoxy-phenyl)-diphenyl-methyl]-amino}-ethyl)-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-methyl)-phosphonic acid bis-[2-(4-nitro-phenyl)-ethyl] ester

Guidance literature:: Multi-step reaction with 4 steps

1: 23 percent / 2.5 h / 100 °C

2: 66 percent / N-ethylmorpholine, HATU / dimethylformamide / 24 h / Ambient temperature

3: 100 percent / TFA / 0 - 10 °C

4: 100 percent / diisopropylethylamine / 12 h / 0 - 5 °C

With N-ethylmorpholine;; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide;
DOI:10.1002/anie.199728091