(S)-2-((S)-2,6-bis-tert-butoxycarbonylaminohexanoylamino)-6-tert-butoxycarbonylaminohexanoic acid benzyl ester

Base Information

• Chemical Name: (S)-2-((S)-2,6-bis-tert-butoxycarbonylaminohexanoylamino)-6-tert-butoxycarbonylaminohexanoic acid benzyl ester
• CAS No.: 1267808-41-2
• Molecular Formula: C₃₄H₅₆N₄O₉
• Molecular Weight: 664.84
• Mol file: 1267808-41-2.mol

Synonyms:(S)-2-((S)-2,6-bis-tert-butoxycarbonylaminohexanoylamino)-6-tert-butoxycarbonylaminohexanoic acid benzyl ester

Chemical Property of (S)-2-((S)-2,6-bis-tert-butoxycarbonylaminohexanoylamino)-6-tert-butoxycarbonylaminohexanoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((S)-2,6-bis-tert-butoxycarbonylaminohexanoylamino)-6-tert-butoxycarbonylaminohexanoic acid benzyl ester

There total 8 articles about (S)-2-((S)-2,6-bis-tert-butoxycarbonylaminohexanoylamino)-6-tert-butoxycarbonylaminohexanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N,N'-di-t-butyloxycarbonyl-(S)-lysine N-hydroxysuccinimide ester (30189-36-7) + (S)-benzyl 2-amino-6-((tert-butoxycarbonyl)amino)hexanoate (114594-04-6) → (S)-2-((S)-2,6-bis-tert-butoxycarbonylaminohexanoylamino)-6-tert-butoxycarbonylaminohexanoic acid benzyl ester (1267808-41-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/ja204422r

Reference yield:

Boc-Lys(Boc)-OH (2483-46-7) + benzyl (2S)-2-amino-6-(tert-butoxycarbonylamino)hexanoate methanesulfonic acid salt → (S)-2-((S)-2,6-bis-tert-butoxycarbonylaminohexanoylamino)-6-tert-butoxycarbonylaminohexanoic acid benzyl ester (1267808-41-2)

Guidance literature:

Boc-Lys(Boc)-OH; benzyl (2S)-2-amino-6-(tert-butoxycarbonylamino)hexanoate methanesulfonic acid salt; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 15 - 20 ℃; for 0.333333h;

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; In tetrahydrofuran; ethyl acetate; at 20 - 25 ℃; for 1.83333h; Cooling;

Reference yield:

(S)-(5-tert-butoxycarbonylamino-5-carbamoyl-pentyl)carbamic acid tert-butyl ester (55592-82-0) + (S)-benzyl 2-amino-6-((tert-butoxycarbonyl)amino)hexanoate (114594-04-6) → (S)-2-((S)-2,6-bis-tert-butoxycarbonylaminohexanoylamino)-6-tert-butoxycarbonylaminohexanoic acid benzyl ester (1267808-41-2)

Guidance literature:

(S)-(5-tert-butoxycarbonylamino-5-carbamoyl-pentyl)carbamic acid tert-butyl ester; With O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.25h;

(S)-benzyl 2-amino-6-((tert-butoxycarbonyl)amino)hexanoate; In dichloromethane; at 20 ℃; for 2h;

upstream raw materials:

Boc-Lys(Boc)-OH

diethylamine

N-ethyl-N,N-diisopropylamine

(S)-6-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid benzyl ester