1-(2-fluoro-2-methyl-propyl)-4-[5-(4-methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidine

Base Information

Chemical Name:1-(2-fluoro-2-methyl-propyl)-4-[5-(4-methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidine
CAS No.:1443155-84-7
Molecular Formula:C₂₄H₃₀FNO₃S
Molecular Weight:431.572
Hs Code.:

Synonyms:1-(2-fluoro-2-methyl-propyl)-4-[5-(4-methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidine

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Chemical Property of 1-(2-fluoro-2-methyl-propyl)-4-[5-(4-methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidine

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Technology Process of 1-(2-fluoro-2-methyl-propyl)-4-[5-(4-methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidine

There total 8 articles about 1-(2-fluoro-2-methyl-propyl)-4-[5-(4-methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1443156-08-8
1-{-4-[5-(4-Methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidin-1-yl}-2-methyl-propan-2-ol

: 1443155-84-7
1-(2-fluoro-2-methyl-propyl)-4-[5-(4-methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidine

Guidance literature:: With (bis-(2-methoxyethyl)amino)sulfur trufluoride; In dichloromethane; toluene; for 16h; Cooling with ice;

Reference yield:

: 1443156-05-5
4-(5-bromo-benzofuran-2-yl)-piperidine-1-carboxylic acid tert-butyl ester

: 1443155-84-7
1-(2-fluoro-2-methyl-propyl)-4-[5-(4-methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane; water / 2.17 h / 100 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 45 °C / 3750.38 Torr

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.08 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / methanol / 20 - 45 °C

5: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; toluene / 16 h

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; toluene;

Reference yield:

: 287192-97-6
4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester

: 1443155-84-7
1-(2-fluoro-2-methyl-propyl)-4-[5-(4-methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidine

Guidance literature:: Multi-step reaction with 7 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 4 h / 75 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 0.5 h / 55 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane; water / 2.17 h / 100 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 45 °C / 3750.38 Torr

5: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.08 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / methanol / 20 - 45 °C

7: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane; toluene / 16 h

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;