1-{-4-[5-(4-Methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidin-1-yl}-2-methyl-propan-2-ol

Base Information

Chemical Name:1-{-4-[5-(4-Methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidin-1-yl}-2-methyl-propan-2-ol
CAS No.:1443156-08-8
Molecular Formula:C₂₄H₃₁NO₄S
Molecular Weight:429.58
Hs Code.:

Synonyms:1-{-4-[5-(4-Methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidin-1-yl}-2-methyl-propan-2-ol

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Chemical Property of 1-{-4-[5-(4-Methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidin-1-yl}-2-methyl-propan-2-ol

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Technology Process of 1-{-4-[5-(4-Methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidin-1-yl}-2-methyl-propan-2-ol

There total 7 articles about 1-{-4-[5-(4-Methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidin-1-yl}-2-methyl-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 558-30-5
2-methyl-1,2-epoxypropane

: 4-[5-(4-methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]piperidine hydrochloride salt

: 1443156-08-8
1-{-4-[5-(4-Methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidin-1-yl}-2-methyl-propan-2-ol

Guidance literature:: 4-[5-(4-methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]piperidine hydrochloride salt; With N-ethyl-N,N-diisopropylamine; In methanol; at 20 ℃; for 0.166667h;

2-methyl-1,2-epoxypropane; In methanol; at 45 ℃;

Reference yield:

: 1443156-05-5
4-(5-bromo-benzofuran-2-yl)-piperidine-1-carboxylic acid tert-butyl ester

: 1443156-08-8
1-{-4-[5-(4-Methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidin-1-yl}-2-methyl-propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane; water / 2.17 h / 100 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 45 °C / 3750.38 Torr

3: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.08 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / methanol / 20 - 45 °C

With hydrogenchloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 287192-97-6
4-ethynyl-piperidine-1-carboxylic acid tert-butyl ester

: 1443156-08-8
1-{-4-[5-(4-Methanesulfonyl-phenyl)-2,3-dihydro-benzofuran-2-yl]-piperidin-1-yl}-2-methyl-propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 4 h / 75 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 0.5 h / 55 °C / Inert atmosphere

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,4-dioxane; water / 2.17 h / 100 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 45 °C / 3750.38 Torr

5: hydrogenchloride / 1,4-dioxane; dichloromethane / 0.08 h / 20 °C

6: N-ethyl-N,N-diisopropylamine / methanol / 20 - 45 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;