(2R,4S)-2-aminomethyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid diphenylmethyl ester

Base Information

• Chemical Name: (2R,4S)-2-aminomethyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid diphenylmethyl ester
• CAS No.: 161563-59-3
• Molecular Formula: C₂₀H₂₄N₂O₂S
• Molecular Weight: 356.489
• Mol file: 161563-59-3.mol

Synonyms:(2R,4S)-2-aminomethyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid diphenylmethyl ester

Chemical Property of (2R,4S)-2-aminomethyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid diphenylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4S)-2-aminomethyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid diphenylmethyl ester

There total 1 articles about (2R,4S)-2-aminomethyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid diphenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,4S)-2-Aminomethyl-5,5-dimethyl-thiazolidine-4-carboxylic acid; hydrochloride + diazodiphenylmethane (908093-98-1) → (2R,4S)-2-aminomethyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid diphenylmethyl ester (161563-59-3)

Guidance literature:

With sodium hydroxide; diethyl ether; In N,N-dimethyl-formamide; at 50 ℃;

DOI:10.1002/ardp.19953280302

Reference yield: 90.0%

1,9-nonanedioic acid pentafluorophenyl ester + (2R,4S)-2-aminomethyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid diphenylmethyl ester (161563-59-3) → (2R,4S)-diphenylmethyl 2-(N-8'-hydroxycarbonyl-1'-octanoyl)aminomethyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylate

Guidance literature:

In dichloromethane; for 16h; Ambient temperature;

DOI:10.1002/ardp.19953280302

Reference yield: 85.0%

phosgene (75-44-5) + (2R,4S)-2-aminomethyl-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid diphenylmethyl ester (161563-59-3) → (3S,7aR)-octahydro-2,2-dimethyl-5-oxopyrrolo<3,4-b>thiazole-3-carboxylic acid diphenylmethyl ester

Guidance literature:

With triethylamine; In dichloromethane; toluene;

DOI:10.1002/ardp.19953280115

upstream raw materials:

diazodiphenylmethane