(-)-(2R)-4-(4-hydroxymethylphenyl)-2-methylthiomethyl-4-oxobutanoic acid

Base Information

• Chemical Name: (-)-(2R)-4-(4-hydroxymethylphenyl)-2-methylthiomethyl-4-oxobutanoic acid
• CAS No.: 211241-35-9
• Molecular Formula: C₁₃H₁₆O₄S
• Molecular Weight: 268.334
• Mol file: 211241-35-9.mol

Synonyms:(-)-(2R)-4-(4-hydroxymethylphenyl)-2-methylthiomethyl-4-oxobutanoic acid

Chemical Property of (-)-(2R)-4-(4-hydroxymethylphenyl)-2-methylthiomethyl-4-oxobutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(2R)-4-(4-hydroxymethylphenyl)-2-methylthiomethyl-4-oxobutanoic acid

There total 5 articles about (-)-(2R)-4-(4-hydroxymethylphenyl)-2-methylthiomethyl-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.6%

(R)-4-(4-methylphenyl)-2-methylthiomethyl-4-oxobutanoix acid (186651-31-0) → (-)-(2R)-4-(4-hydroxymethylphenyl)-2-methylthiomethyl-4-oxobutanoic acid (211241-35-9)

Guidance literature:

With Rhizopus sp. TF₀₀₄₀; In ethanol; at 28 ℃; for 96h; Microbiological reaction;

DOI:10.1271/bbb.62.1048

Reference yield: 24.5%

S-methyl-Esonarimod (143584-75-2) → (-)-(2R)-4-(4-hydroxymethylphenyl)-2-methylthiomethyl-4-oxobutanoic acid (211241-35-9)

Guidance literature:

With Rhizopus sp. TF₀₀₄₀; In ethanol; at 28 ℃; for 96h; Microbiological reaction;

DOI:10.1271/bbb.62.1048

Reference yield:

S-methyl-Esonarimod (143584-75-2) → (+)-(2S)-4-(4-hydroxymethylphenyl)-2-methylthiomethyl-4-oxobutanoic acid + (-)-(2R)-4-(4-hydroxymethylphenyl)-2-methylthiomethyl-4-oxobutanoic acid (211241-35-9)

Guidance literature:

With Mucor circinelloides IFO 4563; Sucrose; In ethanol; at 28 ℃; for 144h; Microbiological reaction;

DOI:10.1271/bbb.62.1048

upstream raw materials:

S-methyl-Esonarimod

(R)-4-(4-methylphenyl)-2-methylthiomethyl-4-oxobutanoix acid

Esonarimod

(R)-Esonarimod

Downstream raw materials:

(-)-(2R)-4-(4-carboxyphenyl)-2-methylthiomethyl-4-oxobutanoic acid