(3R,5S)-4-(4-chlorobenzoyl)-3,5-dimethyl-7-(trifluoromethoxy)-2,3,4,5-tetrahydro-1,4-benzoxazepine

Base Information

Chemical Name:(3R,5S)-4-(4-chlorobenzoyl)-3,5-dimethyl-7-(trifluoromethoxy)-2,3,4,5-tetrahydro-1,4-benzoxazepine
CAS No.:1345731-60-3
Molecular Formula:C₁₉H₁₇ClF₃NO₃
Molecular Weight:399.797
Hs Code.:

Synonyms:(3R,5S)-4-(4-chlorobenzoyl)-3,5-dimethyl-7-(trifluoromethoxy)-2,3,4,5-tetrahydro-1,4-benzoxazepine

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Chemical Property of (3R,5S)-4-(4-chlorobenzoyl)-3,5-dimethyl-7-(trifluoromethoxy)-2,3,4,5-tetrahydro-1,4-benzoxazepine

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Technology Process of (3R,5S)-4-(4-chlorobenzoyl)-3,5-dimethyl-7-(trifluoromethoxy)-2,3,4,5-tetrahydro-1,4-benzoxazepine

There total 8 articles about (3R,5S)-4-(4-chlorobenzoyl)-3,5-dimethyl-7-(trifluoromethoxy)-2,3,4,5-tetrahydro-1,4-benzoxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1345731-93-2
(3R,5S)-3,5-dimethyl-7-(trifluoromethoxy)-2,3,4,5-tetrahydro-1,4-benzoxazepine

: 122-01-0
4-chloro-benzoyl chloride

: 1345731-60-3
(3R,5S)-4-(4-chlorobenzoyl)-3,5-dimethyl-7-(trifluoromethoxy)-2,3,4,5-tetrahydro-1,4-benzoxazepine

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2011.08.093

Reference yield:

: 162270-05-5
2-(methoxymethoxy)-5-(trifluoromethoxy)benzaldehyde

: 1345731-60-3
(3R,5S)-4-(4-chlorobenzoyl)-3,5-dimethyl-7-(trifluoromethoxy)-2,3,4,5-tetrahydro-1,4-benzoxazepine

Guidance literature:: Multi-step reaction with 7 steps

1: diethyl ether / 1 h / 0 °C

2: dipyridinium dichromate / dichloromethane / 44 h / 20 °C

3: hydrogenchloride / tetrahydrofuran; water / Reflux

4: triphenylphosphine; diethylazodicarboxylate / toluene / 2 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 20 °C

6: sodium tetrahydroborate / ethanol / 0 - 20 °C

7: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; dipyridinium dichromate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; toluene;
DOI:10.1016/j.bmcl.2011.08.093

Reference yield:

: 1345731-89-6
1-[2-(methoxymethoxy)-5-(trifluoromethoxy)phenyl]ethanol

: 1345731-60-3
(3R,5S)-4-(4-chlorobenzoyl)-3,5-dimethyl-7-(trifluoromethoxy)-2,3,4,5-tetrahydro-1,4-benzoxazepine

Guidance literature:: Multi-step reaction with 6 steps

1: dipyridinium dichromate / dichloromethane / 44 h / 20 °C

2: hydrogenchloride / tetrahydrofuran; water / Reflux

3: triphenylphosphine; diethylazodicarboxylate / toluene / 2 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

5: sodium tetrahydroborate / ethanol / 0 - 20 °C

6: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; dipyridinium dichromate; triphenylphosphine; trifluoroacetic acid; sodium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1016/j.bmcl.2011.08.093