4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxo-N-(2-oxopyrrolidin-1-yl)but-2-enamide

Base Information

Chemical Name:4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxo-N-(2-oxopyrrolidin-1-yl)but-2-enamide
CAS No.:1310876-08-4
Molecular Formula:C₂₇H₂₂F₃N₃O₅
Molecular Weight:525.484
Hs Code.:

Synonyms:4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxo-N-(2-oxopyrrolidin-1-yl)but-2-enamide

Suppliers and Price of 4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxo-N-(2-oxopyrrolidin-1-yl)but-2-enamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxo-N-(2-oxopyrrolidin-1-yl)but-2-enamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxo-N-(2-oxopyrrolidin-1-yl)but-2-enamide

There total 8 articles about 4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxo-N-(2-oxopyrrolidin-1-yl)but-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 924898-12-4
1-(amino)-2-pyrollidinone p-toluenesulfonate

: 1310875-94-5
4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic acid

: 1310876-08-4
4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxo-N-(2-oxopyrrolidin-1-yl)but-2-enamide

Guidance literature:: 4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxobut-2-enoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 0.5h;

1-(amino)-2-pyrollidinone p-toluenesulfonate; With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 0 - 5 ℃; for 2h;

Reference yield:

: 13472-85-0,1199266-76-6
2-methoxy-5-bromopyridine

: 1310876-08-4
4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxo-N-(2-oxopyrrolidin-1-yl)but-2-enamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: n-butyllithium / cyclohexane; tert-butyl methyl ether / 1.25 h / -32 °C / Inert atmosphere

1.2: -32 - 0 °C / Inert atmosphere

2.1: sodium iodide; triethylsilane / acetonitrile / 20 °C

2.2: 30 °C

3.1: trifluoroacetic acid; acetic acid; N-iodo-succinimide / 20 °C

3.2: Cooling with ice

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h

4.2: 2 h / 20 °C

5.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 70 °C / Inert atmosphere

6.1: sodium t-butanolate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

6.2: 3 h / 20 °C / Inert atmosphere

7.1: hydrogenchloride; water / 1,4-dioxane / 2 h / 95 °C

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h

8.2: 2 h / 0 - 5 °C

With hydrogenchloride; triethylsilane; N-iodo-succinimide; n-butyllithium; water; sodium hydride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; sodium iodide; sodium t-butanolate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; tert-butyl methyl ether; cyclohexane; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1310875-97-8
5-(2,4-difluorobenzyl)-3-iodopyridin-2(1H)-one

: 1310876-08-4
4-(5-(2,4-difluorobenzyl)-1-(2-fluorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2-hydroxy-4-oxo-N-(2-oxopyrrolidin-1-yl)but-2-enamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h

1.2: 2 h / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 70 °C / Inert atmosphere

3.1: sodium t-butanolate / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere

3.2: 3 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride; water / 1,4-dioxane / 2 h / 95 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.5 h

5.2: 2 h / 0 - 5 °C

With hydrogenchloride; water; sodium hydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium t-butanolate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; mineral oil;