(S)-4-((E)-(1S,4R)-4-Benzyloxy-1-methoxymethoxy-pent-2-enyl)-2,2-dimethyl-[1,3]dioxane

Base Information

Chemical Name:(S)-4-((E)-(1S,4R)-4-Benzyloxy-1-methoxymethoxy-pent-2-enyl)-2,2-dimethyl-[1,3]dioxane
CAS No.:204327-28-6
Molecular Formula:C₂₀H₃₀O₅
Molecular Weight:350.455
Hs Code.:

Synonyms:(S)-4-((E)-(1S,4R)-4-Benzyloxy-1-methoxymethoxy-pent-2-enyl)-2,2-dimethyl-[1,3]dioxane

Suppliers and Price of (S)-4-((E)-(1S,4R)-4-Benzyloxy-1-methoxymethoxy-pent-2-enyl)-2,2-dimethyl-[1,3]dioxane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-((E)-(1S,4R)-4-Benzyloxy-1-methoxymethoxy-pent-2-enyl)-2,2-dimethyl-[1,3]dioxane

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-4-((E)-(1S,4R)-4-Benzyloxy-1-methoxymethoxy-pent-2-enyl)-2,2-dimethyl-[1,3]dioxane

There total 7 articles about (S)-4-((E)-(1S,4R)-4-Benzyloxy-1-methoxymethoxy-pent-2-enyl)-2,2-dimethyl-[1,3]dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 107-30-2
chloromethyl methyl ether

: 204327-27-5
(E)-(1S,4R)-4-Benzyloxy-1-((S)-2,2-dimethyl-[1,3]dioxan-4-yl)-pent-2-en-1-ol

: 204327-28-6
(S)-4-((E)-(1S,4R)-4-Benzyloxy-1-methoxymethoxy-pent-2-enyl)-2,2-dimethyl-[1,3]dioxane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 10h; Ambient temperature;
DOI:10.1021/jo972187r

Reference yield:

: 100-39-0
benzyl bromide

: 204327-28-6
(S)-4-((E)-(1S,4R)-4-Benzyloxy-1-methoxymethoxy-pent-2-enyl)-2,2-dimethyl-[1,3]dioxane

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / Ag₂O / diethyl ether / Heating

2: 96 percent / DIBAL / diethyl ether; pentane; hexane / 0.5 h / -78 °C

3: 1.) NaH / 1.) THF, -40 deg C, 40 min, 2.) THF, room temp., 20 h

4: DIBAL, ZnBr₂

5: 90 percent / i-Pr₂NEt / CH₂Cl₂ / 10 h / Ambient temperature

With sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; silver(l) oxide; zinc dibromide; In diethyl ether; hexane; dichloromethane; pentane;
DOI:10.1021/jo972187r

Reference yield:

: 53346-05-7,41954-96-5,81445-44-5,81445-45-6
(R)-2-benzyloxypropanal

: 204327-28-6
(S)-4-((E)-(1S,4R)-4-Benzyloxy-1-methoxymethoxy-pent-2-enyl)-2,2-dimethyl-[1,3]dioxane

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH / 1.) THF, -40 deg C, 40 min, 2.) THF, room temp., 20 h

2: DIBAL, ZnBr₂

3: 90 percent / i-Pr₂NEt / CH₂Cl₂ / 10 h / Ambient temperature

With sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; zinc dibromide; In dichloromethane;
DOI:10.1021/jo972187r