3-[2-[5-[[1-(tert-butoxycarbonyl)-(2S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethylamine

Base Information

Chemical Name:3-[2-[5-[[1-(tert-butoxycarbonyl)-(2S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethylamine
CAS No.:1222139-56-1
Molecular Formula:C₂₃H₃₁N₃O₃
Molecular Weight:397.517
Hs Code.:

Synonyms:3-[2-[5-[[1-(tert-butoxycarbonyl)-(2S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethylamine

Suppliers and Price of 3-[2-[5-[[1-(tert-butoxycarbonyl)-(2S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[2-[5-[[1-(tert-butoxycarbonyl)-(2S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[2-[5-[[1-(tert-butoxycarbonyl)-(2S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethylamine

There total 8 articles about 3-[2-[5-[[1-(tert-butoxycarbonyl)-(2S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74115-13-2
5-bromopyridine-3-ol

: 1222139-56-1
3-[2-[5-[[1-(tert-butoxycarbonyl)-(2S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethylamine

Guidance literature:: Multi-step reaction with 8 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran; toluene / 0.5 h / Cooling with ice; Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine / 16 h / Reflux; Inert atmosphere

3: potassium hydroxide / methanol; hexane / 3 h / 20 °C

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / hexane; ethyl acetate / 18.5 h / 20 °C / Inert atmosphere

5: platinum(IV) oxide; hydrogen / ethyl acetate / 6.25 h / 20 °C

6: 2,6-dimethylpyridine; methanesulfonyl chloride; lithium chloride / N,N-dimethyl-formamide / 20 °C

7: sodium azide / ethyl acetate; N,N-dimethyl-formamide; toluene / 20 °C

8: platinum(IV) oxide; hydrogen / ethanol / 20 °C

With 2,6-dimethylpyridine; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; di-isopropyl azodicarboxylate; hydrogen; methanesulfonyl chloride; triethylamine; triphenylphosphine; lithium chloride; potassium hydroxide; In tetrahydrofuran; methanol; ethanol; hexane; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1222139-54-9
3-[2-[5-[[1-(tert-butoxycarbonyl)-2(S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethyl azide

: 1222139-56-1
3-[2-[5-[[1-(tert-butoxycarbonyl)-(2S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethylamine

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethanol; at 20 ℃;

Reference yield:

: 186593-31-7
(S)-2-(5-bromo-pyridin-3-yloxymethyl)-azetidine-1-carboxylic acid tert-butyl ester

: 1222139-56-1
3-[2-[5-[[1-(tert-butoxycarbonyl)-(2S)-azetidinyl]methoxy]-3-pyridyl]ethyl]phenylmethylamine

Guidance literature:: Multi-step reaction with 7 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; triphenylphosphine / 16 h / Reflux; Inert atmosphere

2: potassium hydroxide / methanol; hexane / 3 h / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / hexane; ethyl acetate / 18.5 h / 20 °C / Inert atmosphere

4: platinum(IV) oxide; hydrogen / ethyl acetate / 6.25 h / 20 °C

5: 2,6-dimethylpyridine; methanesulfonyl chloride; lithium chloride / N,N-dimethyl-formamide / 20 °C

6: sodium azide / ethyl acetate; N,N-dimethyl-formamide; toluene / 20 °C

7: platinum(IV) oxide; hydrogen / ethanol / 20 °C

With 2,6-dimethylpyridine; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; sodium azide; hydrogen; methanesulfonyl chloride; triethylamine; triphenylphosphine; lithium chloride; potassium hydroxide; In methanol; ethanol; hexane; ethyl acetate; N,N-dimethyl-formamide; toluene;