(R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(2,2-diphenylacetyl)ornithinamide

Base Information

Chemical Name:(R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(2,2-diphenylacetyl)ornithinamide
CAS No.:1093677-52-1
Molecular Formula:C₃₈H₄₃N₃O₅
Molecular Weight:621.777
Hs Code.:

Synonyms:(R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(2,2-diphenylacetyl)ornithinamide

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Chemical Property of (R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(2,2-diphenylacetyl)ornithinamide

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Technology Process of (R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(2,2-diphenylacetyl)ornithinamide

There total 4 articles about (R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(2,2-diphenylacetyl)ornithinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1093677-51-0
(R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)ornithinamide

: 226218-61-7
succinimidyl 2,2-diphenylacetate

: 1093677-52-1
(R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(2,2-diphenylacetyl)ornithinamide

Guidance literature:: With triethylamine; In tetrahydrofuran; 1,2-dimethoxyethane; at 35 ℃; for 20h;
DOI:10.1021/jm801018u

Reference yield: 40.0%

: (R)-5-(benzyloxycarbonylamino)-2-(2,2-diphenylacetamido)pentanoic acid

: 84697-13-2
(4-(tert-butoxy)phenyl)methanamine

: 1093677-52-1
(R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(2,2-diphenylacetyl)ornithinamide

Guidance literature:: (R)-5-(benzyloxycarbonylamino)-2-(2,2-diphenylacetamido)pentanoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 0.5h;

(4-(tert-butoxy)phenyl)methanamine; In tetrahydrofuran; at 20 ℃; for 20h; Reagent/catalyst; Solvent; Inert atmosphere;
DOI:10.1071/CH15569

Reference yield:

: 226218-61-7
succinimidyl 2,2-diphenylacetate

: 1093677-52-1
(R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(2,2-diphenylacetyl)ornithinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / 1,4-dioxane; water / 20 h / 50 °C

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h

2.2: 20 h / 20 °C / Inert atmosphere

With sodium carbonate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1071/CH15569