84697-13-2

Usage

Uses

Used in Organic Synthesis:
4-TERT-BUTOXY-BENZYLAMINE is used as a reagent for its ability to facilitate the synthesis of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, making it a valuable component in the creation of new molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-TERT-BUTOXY-BENZYLAMINE serves as a reagent in the development of new drugs. Its properties enable it to be a part of the drug discovery process, potentially leading to the creation of novel pharmaceuticals.
Used as a Building Block in Synthesis:
4-TERT-BUTOXY-BENZYLAMINE is utilized as a building block in the synthesis of pharmaceutical intermediates. Its structural features make it a key component in the assembly of complex organic molecules that are precursors to various medications.
Used as a Stabilizer in Polymer and Resin Production:
This chemical compound is also used as a stabilizer in the production of polymers and resins. Its role in enhancing the stability and performance of these materials is crucial in various applications, from coatings to plastics.
Due to its versatile properties, 4-TERT-BUTOXY-BENZYLAMINE finds a wide range of applications across different industries, making it an essential chemical in modern research and manufacturing processes.

InChI:InChI=1/C11H17NO/c1-11(2,3)13-10-6-4-9(8-12)5-7-10/h4-7H,8,12H2,1-3H3

Upstream product

• 185259-36-3 tert-butyl 4-cyanophenyl ether 
• 507-20-0 tertiary butyl chloride 
• 696-60-6 4-aminomethylphenol 
• 767-00-0 4-cyanophenol 

Downstream Products

• 194207-77-7 (4-tert-Butoxy-benzylamino)-acetonitrile 
• 213820-65-6 (4-tert-Butoxy-benzylamino)-acetic acid ethyl ester 
• 1093677-50-9 (R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(9-fluorenylmethoxycarbonyl)ornithinamide 
• 1314097-00-1 C₂₆H₃₃N₃O₇ 
• 1264494-54-3 C₃₄H₅₇N₇O₇ 
• 1264494-55-4 C₃₆H₆₁N₇O₇ 
• 1264494-61-2 C₄₁H₆₆N₈O₉ 
• 1093677-52-1 (R)-Nδ-benzyloxycarbonyl-N-(4-tert-butoxybenzyl)-Nα-(2,2-diphenylacetyl)ornithinamide 

Relevant academic research and scientific papers

Ammonium Chloride-Promoted Rapid Synthesis of Monosubstituted Ureas under Microwave Irradiation

Monosubstituted ureas are important scaffolds in organic chemistry. They appear in various biologically active compounds and serve as versatile precursors in synthesis. Monosubstituted ureas were originally prepared using toxic and hazardous phosgene equivalents. Modern methods include transamidation of urea and nucleophilic addition to cyanate salts, both of which suffer from a narrow substrate scope due to the need for a strong acid and prolonged reaction times. We hereby report that ammonium chloride can promote the reaction between amines and potassium cyanate to generate monosubstituted ureas in water. This method proceeds rapidly under microwave irradiation and tolerates a broad range of functional groups. Unlike previous strategies, it is compatible with other nucleophiles, acid-labile moieties, and most of the common protecting groups. The products precipitate out of solution, allowing facile isolation without column chromatography.

Convenient two-step synthesis of highly functionalized benzo-fused 1,4-diazepin-3-ones and 1,5-diazocin-4-ones by sequential Ugi and intramolecular SNAr reactions

Benzodiazepinones are an important family of heterocycles with very attractive pharmacological properties and peptidomimetic abilities. We report herein a rapid and efficient two-step synthesis of polysubstituted 1,4-benzodiazepin-3-ones and 1,5-benzodiazocin-4-ones using a multicomponent condensation/cyclization strategy. The approach uses an Ugi four-component reaction to condense readily available Nα-Fmoc-amino acids, amines and isocyanides with a 2-fluorobenzaldehyde derivative followed by a one-pot Fmoc-group removal, intramolecular aromatic nucleophilic substitution for ring closure and side chain deprotection. The described method gives access to benzo-fused 7- and 8-membered rings bearing a wide variety of functionalized substituents and was applied to efficiently prepare tri- and tetrasubstituted 1,4-benzodiazepin-3-ones and 1,5-benzodiazocin-4-ones in high yields in two straightforward steps.

INHIBITORS FOR PROLIFERATING CELL NUCLEAR ANTIGEN AND USES

The present invention relates to series of compounds as an inhibitor targeting Proliferating Cell Nuclear Antigen (PCNA). Pharmaceutical compositions of those compounds and methods of using them in the treatment of cancer are within the scope of this disclosure.

Guanidine-acylguanidine bioisosteric approach in the design of radioligands: Synthesis of a tritium-labeled NG-propionylargininamide ([3H]-UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist

Synthesis and characterization of (R)-Nα-(2,2- diphenylacetyl)-N-(4-hydroxybenzyl)-Nω-([2,3- 3H]-propanoyl)-argininamide ([3H]-UR-MK114), an easily accessible tritium-labeled NPY Y1 receptor (Y1R) antagonist (KB: 0.8 nM, calcium assay, HEL cells) derived from the (R)-argininamide BIBP 3226, is reported. The radioligand binds with high affinity (KD, saturation: 1.2 nM, kinetic experiments: 1.1 nM, SK-N-MC cells) and selectivity for Y1R over Y2, Y 4, and Y5 receptors. The title compound is a useful pharmacological tool for the determination of Y1R ligand affinities, quantification of Y1R binding sites, and autoradiography.

Protection of phenols as t-butyl ethers under mild conditions

Zinc mediated selective O-y-butylation of phenols has been carried out in good to excellent yields under mild conditions. No trace of C-t-butylation was observed.

Solid-phase syntheses of peptoids using Fmoc-protected N-substituted glycines: The synthesis of (retro)peptoids of leu-enkephalin and substance P

A particularly interesting class of oligomeric peptidomimetics is formed by the peptoids, which consist of N-substituted glycine residues. A solid- phase synthesis method for peptoids is presented in which these residues are introduced using their Fmoc derivatives. This 'monomer' method allowed the monitored synthesis of relatively large quantities of pure peptoids as well as the translation of, in principle, any peptide into the corresponding peptoid. The required Fmoc-substituted glycines were accessible by convenient synthesis, and a number of monomers including those containing side chains with functional groups have been synthesized. The use of Fmoc monomers also allowed implementation of a solid-phase synthesis protocol on a commercial peptide synthesizer. The method was exempli- fled by the solid-phase syntheses of the (retro)peptoids of Leu-enkephalin and substance P. Mass spectrometric studies of (retro)peptoids were essential for their characterization, and the presence of the B- and Y'- type ions allows sequence analysis. Substance P (retro)peptoids were biologically active. HPLC analysis showed an increased hydrophobicity, and pepsin treatment resulted in greatly reduced degradation compared with the corresponding peptide.