(R)-2-benzyloxycarbonylamino-3,3-dimethylbutanenitrile

Base Information

• Chemical Name: (R)-2-benzyloxycarbonylamino-3,3-dimethylbutanenitrile
• CAS No.: 1355742-77-6
• Molecular Formula: C₁₄H₁₈N₂O₂
• Molecular Weight: 246.309
• Mol file: 1355742-77-6.mol

Synonyms:(R)-2-benzyloxycarbonylamino-3,3-dimethylbutanenitrile

Chemical Property of (R)-2-benzyloxycarbonylamino-3,3-dimethylbutanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-benzyloxycarbonylamino-3,3-dimethylbutanenitrile

There total 1 articles about (R)-2-benzyloxycarbonylamino-3,3-dimethylbutanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

trimethylsilyl cyanide (7677-24-9) + C13H17NO2 (1355742-55-0) → (R)-2-benzyloxycarbonylamino-3,3-dimethylbutanenitrile (1355742-77-6)

Guidance literature:

trimethylsilyl cyanide; With methanol; [Ru{(S)-phgly}2{(S)-binap}]; at 0 ℃; for 0.25h; Inert atmosphere;

C₁₃H₁₇NO₂; In tert-butyl methyl ether; at 0 ℃; for 0.25h; Inert atmosphere;

With lithium phenolate; In tetrahydrofuran; tert-butyl methyl ether; at -20 ℃; for 0.5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol203408w

Reference yield: 92.0%

(R)-2-benzyloxycarbonylamino-3,3-dimethylbutanenitrile (1355742-77-6) → D-tert-leucine (26782-71-8)

Guidance literature:

With hydrogenchloride; sulfuric acid; In water; at 120 ℃; for 44h; enantioselective reaction;

DOI:10.1021/ol203408w

upstream raw materials:

trimethylsilyl cyanide

C₁₃H₁₇NO₂

Downstream raw materials:

D-tert-leucine