5-benzyloxycarbonylamino-2-(2-benzyl-3,3,3-trifluoro-2-methylamino-propionylamino)-pentanoic acid tert-butyl ester

Base Information

Chemical Name:5-benzyloxycarbonylamino-2-(2-benzyl-3,3,3-trifluoro-2-methylamino-propionylamino)-pentanoic acid tert-butyl ester
CAS No.:881853-75-4
Molecular Formula:C₂₈H₃₆F₃N₃O₅
Molecular Weight:551.606
Hs Code.:

5-benzyloxycarbonylamino-2-(2-benzyl-3,3,3-trifluoro-2-methylamino-propionylamino)-pentanoic acid <i>tert</i>-butyl ester

Synonyms:5-benzyloxycarbonylamino-2-(2-benzyl-3,3,3-trifluoro-2-methylamino-propionylamino)-pentanoic acid tert-butyl ester

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Chemical Property of 5-benzyloxycarbonylamino-2-(2-benzyl-3,3,3-trifluoro-2-methylamino-propionylamino)-pentanoic acid tert-butyl ester

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Technology Process of 5-benzyloxycarbonylamino-2-(2-benzyl-3,3,3-trifluoro-2-methylamino-propionylamino)-pentanoic acid tert-butyl ester

There total 2 articles about 5-benzyloxycarbonylamino-2-(2-benzyl-3,3,3-trifluoro-2-methylamino-propionylamino)-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 160511-12-6
4-benzyl-3-methyl-4-trifluoromethyl-oxazolidine-2,5-dione

: 161234-80-6
N⁵-[(phenylmethoxy)carbonyl]-L-ornithine 1,1-dimethylethyl ester hydrochloride

: 881853-75-4
5-benzyloxycarbonylamino-2-(2-benzyl-3,3,3-trifluoro-2-methylamino-propionylamino)-pentanoic acid tert-butyl ester

Guidance literature:: With TEA; In dichloromethane; at 20 ℃;
DOI:10.1021/jm0511334

Reference yield:

: 139520-49-3
4-Benzyl-4-trifluoromethyl-oxazolidine-2,5-dione

: 881853-75-4
5-benzyloxycarbonylamino-2-(2-benzyl-3,3,3-trifluoro-2-methylamino-propionylamino)-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide

1.2: dimethylformamide

2.1: TEA / CH₂Cl₂ / 20 °C

With TEA; sodium hydride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0511334

Reference yield:

: 881853-75-4
5-benzyloxycarbonylamino-2-(2-benzyl-3,3,3-trifluoro-2-methylamino-propionylamino)-pentanoic acid tert-butyl ester

: ((S)-2-{2-[((S)-2-Amino-3-phenyl-propionyl)-methyl-amino]-2-benzyl-3,3,3-trifluoro-propionylamino}-5-benzyloxycarbonylamino-pentanoylamino)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1-bromo-N,N,2-trimethyl-1,1-propenylamine; collidine / CH₂Cl₂ / 5 h

2: TFA / CH₂Cl₂ / 1 h

3: HOAT; DCC; DIEA / CH₂Cl₂ / 2 h

4: [Et₃NH][Sn(SPh)3] / acetonitrile / 1 h / 20 °C

With 2,3,5-trimethyl-pyridine; 1-hydroxy-7-aza-benzotriazole; 1-bromo-N,N,2-trimethyl-1-propen-1-amine; [Et₃NH][Sn(SPh)3]; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1021/jm0511334