4-Methoxy-3-[(6E,8E,10E)-(2R,4S)-1-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-dodeca-6,8,10-trienyl]-5-methylene-5H-furan-2-one

Base Information

Chemical Name:4-Methoxy-3-[(6E,8E,10E)-(2R,4S)-1-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-dodeca-6,8,10-trienyl]-5-methylene-5H-furan-2-one
CAS No.:897014-84-5
Molecular Formula:C₂₈H₃₄O₆
Molecular Weight:466.574
Hs Code.:

Synonyms:4-Methoxy-3-[(6E,8E,10E)-(2R,4S)-1-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-dodeca-6,8,10-trienyl]-5-methylene-5H-furan-2-one

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Chemical Property of 4-Methoxy-3-[(6E,8E,10E)-(2R,4S)-1-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-dodeca-6,8,10-trienyl]-5-methylene-5H-furan-2-one

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Technology Process of 4-Methoxy-3-[(6E,8E,10E)-(2R,4S)-1-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-dodeca-6,8,10-trienyl]-5-methylene-5H-furan-2-one

There total 9 articles about 4-Methoxy-3-[(6E,8E,10E)-(2R,4S)-1-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-dodeca-6,8,10-trienyl]-5-methylene-5H-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 897014-72-1
3-[(6E,8E,10E)-(2R,4S)-5-Hydroxy-1-(4-methoxy-benzyloxy)-2,4-dimethyl-dodeca-6,8,10-trienyl]-4-methoxy-5-methylene-5H-furan-2-one

: 897014-84-5
4-Methoxy-3-[(6E,8E,10E)-(2R,4S)-1-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-dodeca-6,8,10-trienyl]-5-methylene-5H-furan-2-one

Guidance literature:: With manganese(IV) oxide; In diethyl ether; at 20 ℃; for 3h;
DOI:10.1016/j.tet.2006.01.106

Reference yield:

: (1E,3E,5E)-1-Iodo-hepta-1,3,5-triene

: 897014-84-5
4-Methoxy-3-[(6E,8E,10E)-(2R,4S)-1-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-dodeca-6,8,10-trienyl]-5-methylene-5H-furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 40 percent / CrCl₂; NiCl₂ / tetrahydrofuran; dimethylsulfoxide / 12 h / 20 °C

2: 90 percent / MnO₂ / diethyl ether / 3 h / 20 °C

With chromium dichloride; manganese(IV) oxide; nickel dichloride; In tetrahydrofuran; diethyl ether; dimethyl sulfoxide; 1: Kishi reaction;
DOI:10.1016/j.tet.2006.01.106

Reference yield:

: 897014-69-6
Acetic acid (2S,4R)-5-hydroxy-5-(4-methoxy-5-methylene-2-oxo-2,5-dihydro-furan-3-yl)-2,4-dimethyl-pentyl ester

: 897014-84-5
4-Methoxy-3-[(6E,8E,10E)-(2R,4S)-1-(4-methoxy-benzyloxy)-2,4-dimethyl-5-oxo-dodeca-6,8,10-trienyl]-5-methylene-5H-furan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / (+/-)-camphorsulfonic acid / CH₂Cl₂; cyclohexane / 7 h / 0 - 20 °C

2: 81 percent / Amano lipase AK; sodium phosphate buffer / acetonitrile / 12 h / 20 °C / pH 6.2

3: 88 percent / IBX / dimethylsulfoxide / 2 h / 20 °C

4: 40 percent / CrCl₂; NiCl₂ / tetrahydrofuran; dimethylsulfoxide / 12 h / 20 °C

5: 90 percent / MnO₂ / diethyl ether / 3 h / 20 °C

With chromium dichloride; manganese(IV) oxide; sodium phosphate buffer; Amano Lipase AK; camphor-10-sulfonic acid; nickel dichloride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; dimethyl sulfoxide; acetonitrile; 4: Kishi reaction;
DOI:10.1016/j.tet.2006.01.106