(2S,4R)-5-(4-Methoxy-benzyloxy)-5-(4-methoxy-5-methylene-2-oxo-2,5-dihydro-furan-3-yl)-2,4-dimethyl-pentanal

Base Information

Chemical Name:(2S,4R)-5-(4-Methoxy-benzyloxy)-5-(4-methoxy-5-methylene-2-oxo-2,5-dihydro-furan-3-yl)-2,4-dimethyl-pentanal
CAS No.:897014-81-2
Molecular Formula:C₂₁H₂₆O₆
Molecular Weight:374.434
Hs Code.:

Synonyms:(2S,4R)-5-(4-Methoxy-benzyloxy)-5-(4-methoxy-5-methylene-2-oxo-2,5-dihydro-furan-3-yl)-2,4-dimethyl-pentanal

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Chemical Property of (2S,4R)-5-(4-Methoxy-benzyloxy)-5-(4-methoxy-5-methylene-2-oxo-2,5-dihydro-furan-3-yl)-2,4-dimethyl-pentanal

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Technology Process of (2S,4R)-5-(4-Methoxy-benzyloxy)-5-(4-methoxy-5-methylene-2-oxo-2,5-dihydro-furan-3-yl)-2,4-dimethyl-pentanal

There total 5 articles about (2S,4R)-5-(4-Methoxy-benzyloxy)-5-(4-methoxy-5-methylene-2-oxo-2,5-dihydro-furan-3-yl)-2,4-dimethyl-pentanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 897014-71-0
3-[(2R,4S)-5-Hydroxy-1-(4-methoxy-benzyloxy)-2,4-dimethyl-pentyl]-4-methoxy-5-methylene-5H-furan-2-one

: 897014-81-2
(2S,4R)-5-(4-Methoxy-benzyloxy)-5-(4-methoxy-5-methylene-2-oxo-2,5-dihydro-furan-3-yl)-2,4-dimethyl-pentanal

Guidance literature:: With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 20 ℃; for 2h;
DOI:10.1016/j.tet.2006.01.106

Reference yield:

: 897014-69-6
Acetic acid (2S,4R)-5-hydroxy-5-(4-methoxy-5-methylene-2-oxo-2,5-dihydro-furan-3-yl)-2,4-dimethyl-pentyl ester

: 897014-81-2
(2S,4R)-5-(4-Methoxy-benzyloxy)-5-(4-methoxy-5-methylene-2-oxo-2,5-dihydro-furan-3-yl)-2,4-dimethyl-pentanal

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / (+/-)-camphorsulfonic acid / CH₂Cl₂; cyclohexane / 7 h / 0 - 20 °C

2: 81 percent / Amano lipase AK; sodium phosphate buffer / acetonitrile / 12 h / 20 °C / pH 6.2

3: 88 percent / IBX / dimethylsulfoxide / 2 h / 20 °C

With sodium phosphate buffer; Amano Lipase AK; camphor-10-sulfonic acid; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dichloromethane; cyclohexane; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.tet.2006.01.106

Reference yield:

: 897014-78-7
Acetic acid (2S,4R)-5-(4-methoxy-benzyloxy)-5-(4-methoxy-5-methylene-2-oxo-2,5-dihydro-furan-3-yl)-2,4-dimethyl-pentyl ester

: 897014-81-2
(2S,4R)-5-(4-Methoxy-benzyloxy)-5-(4-methoxy-5-methylene-2-oxo-2,5-dihydro-furan-3-yl)-2,4-dimethyl-pentanal

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / Amano lipase AK; sodium phosphate buffer / acetonitrile / 12 h / 20 °C / pH 6.2

2: 88 percent / IBX / dimethylsulfoxide / 2 h / 20 °C

With sodium phosphate buffer; Amano Lipase AK; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; acetonitrile;
DOI:10.1016/j.tet.2006.01.106