2-acetamido-N-benzyl-2-(trimethylammonio)acetamide tetrafluoroborate

Base Information

• Chemical Name: 2-acetamido-N-benzyl-2-(trimethylammonio)acetamide tetrafluoroborate
• CAS No.: 133873-22-0
• Molecular Formula: BF₄*C₁₄H₂₂N₃O₂
• Molecular Weight: 351.152
• Mol file: 133873-22-0.mol

Synonyms:2-acetamido-N-benzyl-2-(trimethylammonio)acetamide tetrafluoroborate

Chemical Property of 2-acetamido-N-benzyl-2-(trimethylammonio)acetamide tetrafluoroborate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-acetamido-N-benzyl-2-(trimethylammonio)acetamide tetrafluoroborate

There total 3 articles about 2-acetamido-N-benzyl-2-(trimethylammonio)acetamide tetrafluoroborate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

trimethoxonium tetrafluoroborate (420-37-1) + 2-acetamido-N-benzyl-2-(N,N-dimethylamino)-acetamide (133873-20-8) → 2-acetamido-N-benzyl-2-(trimethylammonio)acetamide tetrafluoroborate (133873-22-0)

Guidance literature:

In nitromethane; for 2h; Ambient temperature;

DOI:10.1021/jm00112a020

Reference yield:

α-acetamido-N-benzyl-α-ethoxyacetamide (117422-80-7) → 2-acetamido-N-benzyl-2-(trimethylammonio)acetamide tetrafluoroborate (133873-22-0)

Guidance literature:

Multi-step reaction with 3 steps

1: BBr₃ / CH₂Cl₂ / 5 h / Ambient temperature

2: tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) RT, 90 min

3: 72 percent / nitromethane / 2 h / Ambient temperature

With boron tribromide; In tetrahydrofuran; nitromethane; dichloromethane;

DOI:10.1021/jm00112a020

Reference yield:

α-acetamido-N-benzyl-α-bromoacetamide (133873-18-4) → 2-acetamido-N-benzyl-2-(trimethylammonio)acetamide tetrafluoroborate (133873-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 1.) -78 deg C, 30 min, 2.) RT, 90 min

2: 72 percent / nitromethane / 2 h / Ambient temperature

In tetrahydrofuran; nitromethane;

DOI:10.1021/jm00112a020

upstream raw materials:

trimethoxonium tetrafluoroborate

2-acetamido-N-benzyl-2-(N,N-dimethylamino)-acetamide

α-acetamido-N-benzyl-α-ethoxyacetamide

α-acetamido-N-benzyl-α-bromoacetamide

Downstream raw materials:

2-acetamido-N-benzyl-2-(N-(N-methylhydroxyamino))acetamide

2-acetamido-N-benzyl-2-[methoxy(methyl)amino]acetamide

methyl N-glycinate

2-acetamido-N-benzyl-2-(methoxyamino)acetamide