133873-18-4Relevant academic research and scientific papers
Synthesis and anticonvulsant activities of α-acetamido-N-benzylacetamide derivatives containing an electron-deficient α-heteroaromatic substituent
Bardel,Bolanos,Kohn
, p. 4567 - 4571 (1994)
Recent studies have demonstrated that C(α)-substituted α-acetamido-N- benzylacetamides displayed excellent anticonvulsant activities in mice. Analysis of the structure-activity relationship for this series of compounds has shown that placement of small, e
Amino acid derivative anticonvulsant
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, (2008/06/13)
The present invention relates to compounds of the formula STR1
Amino acid derivative anticonvulsant
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, (2008/06/13)
The present invention relates to compounds exhibiting central nervous system (CNS) activity which are useful in the treatment of epilepsy and other CNS disorders. The compounds of this invention have the following general formula: STR1 and pharmaceutically acceptable salts thereof.
Synthesis and Anticonvulsant Activities of α-Heterocyclic α-Acetamido-N-benzylacetamide Derivatives
Kohn, Harold,Sawhney, Kailash N.,Bardel, Patrick,Robertson, David W.,Leander, J. David
, p. 3350 - 3360 (2007/10/02)
Earlier studies showed that (R,S)-α-acetamido-N-benzylacetamides (2) containing a five- and six-membered aromatic or heteroaromatic group appended at the C(α) site displayed outstanding activity in the maximal electroshock-induced seizure (MES) test in mi
Preparation and anticonvulsant activity of a series of functionalized α-heteroatom-substituted amino acids
Kohn,Sawhney,LeGall,Robertson,Leander
, p. 2444 - 2452 (2007/10/02)
Potent anticonvulsant activity has been reported for (R,S)-2-acetamido-N-benzyl-2-methylacetamide (2a). Select α-heteroatom substituted derivatives of 2a have been prepared (26 examples) in which the α-methyl group has been replaced by nitrogen (3a-q), ox
