Technology Process of (2RS)-7-methoxy-1'-[2-(2-methylphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one
There total 8 articles about (2RS)-7-methoxy-1'-[2-(2-methylphenyl)ethyl]-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2RS)-7-methoxy-3,4-dihydro-1H-spiro[naphthalene-2,2'-piperidin]-1-one;
With
potassium carbonate; N-ethyl-N,N-diisopropylamine;
In
toluene;
at 20 ℃;
for 1h;
1-(2-iodoethyl)-2-methylbenzene;
In
toluene;
for 36h;
Reflux;
DOI:10.1016/j.bmc.2017.05.012
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine; chloroformic acid ethyl ester / tetrahydrofuran / 0.5 h / -20 - -15 °C
1.2: 3 h / 20 °C
2.1: trichlorophosphate; pyridine / tetrahydrofuran; N,N-dimethyl-formamide / 27 h / 0 - 80 °C
3.1: lithium diisopropyl amide / tetrahydrofuran / 3.25 h / -78 - 20 °C / Inert atmosphere
4.1: aluminum (III) chloride / toluene / 5 h / 85 °C
4.2: 48 h / 85 °C
5.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / toluene / 1 h / 20 °C
5.2: 36 h / Reflux
With
pyridine; aluminum (III) chloride; chloroformic acid ethyl ester; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide; trichlorophosphate;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.bmc.2017.05.012
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 3.25 h / -78 - 20 °C / Inert atmosphere
2.1: aluminum (III) chloride / toluene / 5 h / 85 °C
2.2: 48 h / 85 °C
3.1: potassium carbonate; N-ethyl-N,N-diisopropylamine / toluene / 1 h / 20 °C
3.2: 36 h / Reflux
With
aluminum (III) chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; lithium diisopropyl amide;
In
tetrahydrofuran; toluene;
DOI:10.1016/j.bmc.2017.05.012