1-(3-O-benzoyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-2-O-trifluoromethanesulfonyl-β-D-threo-pentofuranosyl)thymine

Base Information

Chemical Name:1-(3-O-benzoyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-2-O-trifluoromethanesulfonyl-β-D-threo-pentofuranosyl)thymine
CAS No.:740853-16-1
Molecular Formula:C₂₁H₂₃F₃N₂O₁₄S₃
Molecular Weight:680.612
Hs Code.:

Synonyms:1-(3-O-benzoyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-2-O-trifluoromethanesulfonyl-β-D-threo-pentofuranosyl)thymine

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Chemical Property of 1-(3-O-benzoyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-2-O-trifluoromethanesulfonyl-β-D-threo-pentofuranosyl)thymine

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Technology Process of 1-(3-O-benzoyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-2-O-trifluoromethanesulfonyl-β-D-threo-pentofuranosyl)thymine

There total 5 articles about 1-(3-O-benzoyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-2-O-trifluoromethanesulfonyl-β-D-threo-pentofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358-23-6
trifluoromethylsulfonic anhydride

: 625111-33-3
1-(3-O-benzoyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-β-D-threo-pentofuranosyl)thymine

: 740853-16-1
1-(3-O-benzoyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-2-O-trifluoromethanesulfonyl-β-D-threo-pentofuranosyl)thymine

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1055/s-2004-815959

Reference yield:

: 1025373-45-8
trifluoromethanesulfonic acid anhydride

: 625111-33-3
1-(3-O-benzoyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-β-D-threo-pentofuranosyl)thymine

: 740853-16-1
1-(3-O-benzoyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-2-O-trifluoromethanesulfonyl-β-D-threo-pentofuranosyl)thymine

Guidance literature:: trifluoromethanesulfonic acid anhydride; 1-(3-O-benzoyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-β-D-threo-pentofuranosyl)thymine; With pyridine; dmap; In dichloromethane; at 0 ℃; for 1h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 552856-38-9
2,2'-anhydro-1-(3-O-benzyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-β-D-threo-pentofuranosyl)thymine

: 740853-16-1
1-(3-O-benzoyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-2-O-trifluoromethanesulfonyl-β-D-threo-pentofuranosyl)thymine

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / methanol; acetone / 23 h / 20 °C

2: pyridine / dimethylformamide / 18 h / 20 °C

3: 25.1 g / aq. H₂SO₄ / 22 h / 80 °C

4: pyridine; DMAP / CH₂Cl₂ / 1 h / 0 °C

With pyridine; dmap; sulfuric acid; hydrogen; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1055/s-2004-815959