625111-33-3

Upstream product

• 552856-38-9 2,2'-anhydro-1-(3-O-benzyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-β-D-threo-pentofuranosyl)thymine 
• 98-88-4 benzoyl chloride 
• 740853-14-9 2,2'-anhydro-1-(3-O-benzoyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-β-D-threo-pentofuranosyl)thymine 

Downstream Products

• 740853-16-1 1-(3-O-benzoyl-5-O-methanesulfonyl-4-C-methanesulfonyloxymethyl-2-O-trifluoromethanesulfonyl-β-D-threo-pentofuranosyl)thymine 
• 625111-36-6 (1R,3R,4R,7R)-7-benzoyloxy-1-benzoyloxymethyl-3-(thymin-1-yl)-2-oxa-5-thiabicyclo[2.2.1]heptane 
• 625111-35-5 (1R,3R,4R,7R)-7-benzoyloxy-1-methanesulfonyloxymethyl-3-(thymin-1-yl)-2-oxa-5-thiabicyclo[2.2.1]heptane 

Relevant academic research and scientific papers

Oligomeric compounds for the modulation survivin expression

Oligonucleotides directed against the survivin gene are provided for modulating the expression of survivin. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the survivin. Methods of using these compounds for modulation of survivin expression and for the treatment of diseases associated with either overexpression of survivin, expression of mutated survivin or both are provided. Examples of diseases are cancer such as lung, breast, colon, prostate, pancreas, lung, liver, thyroid, kidney, brain, testes, stomach, intestine, bowel, spinal cord, sinuses, bladder, urinary tract or ovaries cancers. The oligonucleotides may be composed of deoxyribonucleosides or a nucleic acid analogue such as for example locked nucleic acid or a combination thereof.

Synthesis of locked nucleic acid derivatives

The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α-L-oxy-LNA, amino-LNA, α-L-amino-LNA, thio-LNA, α-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising

Analogues of LNA (Locked Nucleic Acid): Synthesis of the 2′-thio-LNA ribothymidine and 5-methylcytidine phosphoramidites

The bicyclic 2′-thio-LNA ribothymidine phosphoramidite (13) has been synthesised using a strategy making the synthesis of 2′-thio-LNA convergent with the syntheses of LNA and 2′-amino-LNA. The key step was the formation of anhydro-nucleoside 4 that preven

Oligomeric compounds for the modulation of ras expression

Oligonucleotides directed against the Ha-ras gene are provided for modulating the expression of Ha-ras. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding the Ha-ras. Methods of using th

SYNTHESIS OF LOCKED NUCLEIC ACID DERIVATIVES

The invention relates to a novel strategy for the synthesis of Locked Nucleic Acid derivatives, such as α-L-oxy-LNA, amino-LNA, α-L-amino-LNA, thio-LNA, α-L-thio-LNA, seleno-LNA and methylene LNA, which provides scalable high yielding reactions utilising