N-[2-(1-hydroxyprop-2-yn-1-yl)phenyl]-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-[2-(1-hydroxyprop-2-yn-1-yl)phenyl]-4-methylbenzenesulfonamide
• CAS No.: 1315477-55-4
• Molecular Formula: C₁₆H₁₅NO₃S
• Molecular Weight: 301.366
• Mol file: 1315477-55-4.mol

Synonyms:N-[2-(1-hydroxyprop-2-yn-1-yl)phenyl]-4-methylbenzenesulfonamide

Chemical Property of N-[2-(1-hydroxyprop-2-yn-1-yl)phenyl]-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[2-(1-hydroxyprop-2-yn-1-yl)phenyl]-4-methylbenzenesulfonamide

There total 10 articles about N-[2-(1-hydroxyprop-2-yn-1-yl)phenyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide (6590-65-4) + acetylene (74-86-2,25067-58-7) → N-[2-(1-hydroxyprop-2-yn-1-yl)phenyl]-4-methylbenzenesulfonamide (1315477-55-4)

Guidance literature:

acetylene; With ethylmagnesium bromide; In tetrahydrofuran; at 50 ℃; for 1h;

N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide; In tetrahydrofuran; at 20 ℃; for 0.333333h;

DOI:10.1021/acs.joc.0c00245

Reference yield: 78.0%

C9H9NO (1379771-04-6) + p-toluenesulfonyl chloride (98-59-9) → N-[2-(1-hydroxyprop-2-yn-1-yl)phenyl]-4-methylbenzenesulfonamide (1315477-55-4)

Guidance literature:

With pyridine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo300458v

Reference yield:

o-aminobenzaldehyde (529-23-7) → N-[2-(1-hydroxyprop-2-yn-1-yl)phenyl]-4-methylbenzenesulfonamide (1315477-55-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / 4 h / 20 °C / Inert atmosphere

2.1: tetrahydrofuran / 3 h / Reflux; Inert atmosphere

2.2: 0.17 h / 20 °C / Inert atmosphere; Saturated solution

With pyridine; In tetrahydrofuran;

DOI:10.1021/jo201208e

upstream raw materials:

o-aminobenzaldehyde

p-toluenesulfonyl chloride

C₉H₉NO

2-nitro-benzaldehyde

Downstream raw materials:

4-methyl-N-[2-(prop-2-yn-1-yl)phenyl]benzenesulfonamide

1-tosyl-1,4-dihydroquinoline

2-(iodomethylene)-1-tosylindolin-3-one

2-(iodomethylene)-1-tosylindolin-3-one