6590-65-4

Usage

Uses

Used in Pharmaceutical Industry:
N-(2-Formylphenyl)-4-methyl-benzenesulfonamide is used as an intermediate in the synthesis of pharmaceutical drugs for its potential antimicrobial properties and its ability to be incorporated into various drug molecules.
Used in Chemical Research:
N-(2-FORMYLPHENYL)-4-METHYL-BENZENESULF& is used in chemical research to study the properties and reactions of sulfonamide derivatives, which can lead to the development of new compounds and applications in various fields.
Used in Antimicrobial Applications:
N-(2-Formylphenyl)-4-methyl-benzenesulfonamide may be used as an antimicrobial agent due to the general properties of sulfonamides, which can be effective against certain bacteria and other microorganisms.
(Note: The specific uses mentioned above are hypothetical and based on the general properties of sulfonamides. Further research and testing would be required to confirm the exact applications and efficacy of N-(2-Formylphenyl)-4-methyl-benzenesulfonamide.)

InChI:InChI=1/C14H13NO3S/c1-11-6-8-13(9-7-11)19(17,18)15-14-5-3-2-4-12(14)10-16/h2-10,15H,1H3

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 70-55-3 toluene-4-sulfonamide 
• 529-23-7 o-aminobenzaldehyde 
• 98-59-9 p-toluenesulfonyl chloride 
• 90312-02-0 N-(2-hydroxymethylphenyl)-4-methylbenzenesulfonamide 
• 5344-90-1 2-Aminobenzyl alcohol 
• 50998-74-8 methyl N-tosylanthranilate 
• 134-20-3 2-carbomethoxyaniline 
• 111881-64-2 (2-hydroxymethyl-phenyl)-carbamic acid benzyl ester 
• 118-92-3 anthranilic acid 
• 6311-23-5 2-(toluene-4-sulfonylamino)-benzoic acid 
• 552-89-6 2-nitro-benzaldehyde 
• 941-55-9 4-toluenesulfonyl azide 
• 51608-60-7 N-(benzylidene)-p-methylbenzenesulfonamide 

Downstream Products

• 122392-99-8 N-(o-tosylaminobenzylidene)methylamine 
• 182145-40-0 N-[2-(1-Hydroxyhept-6-enyl)phenyl]-4-methylbenzenesulfonamide 
• 705256-10-6 N-[2-(benzyloxyimino-methyl)-phenyl]-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Phosphine-catalyzed [4+1] annulation of 2-tosylaminochalcones with allenoates: Synthesis of trans-2,3-disubstitued indolines

Phosphine-catalyzed [4+1] annulation of 2-tosylaminochalcones with allenoates has been achieved, giving trans-2,3-disubstitued indolines as major diastereoisomers in moderate to good yields.

Ruthenium-catalyzed C-H amination of aroylsilanes

Acylsilane represents a valuable synthon in synthetic chemistry. We report on ruthenium(ii)-catalyzedortho-C-H amination of aroylsilanes to provide facile access to synthetically useful imidobenzoylsilanes and tosyl-amidobenzoylsilanes. The protocols, with broad substrate scope and excellent functional group tolerance, are enabled with the weak chelation-assistance of acylsilaneviaC-H cyclometallation.

A new route to 1,2,3-triazole fused benzooxazepine and benzodiazepine analogues through metal-free intramolecular azide-olefin oxidative cycloaddition

A collection of 1,2,3-triazole fused benzooxazepine and benzodiazepine analogues was prepared by one pot azide substitution and intramolecular azide-olefin oxidative cycloaddition sequence under metal-free conditions.

One-Pot Relay Gold(I) and Br?nsted Acid Catalysis: Cyclopenta[b]annulation of Indoles via Hydroamination/Nazarov-Type Cyclization Cascade of Enynols

An expedient relay gold(I) and Br?nsted acid catalyzed hydroamination/Nazarov cyclization of 1-(2-aminophenyl)pent-4-en-2-ynols for the synthesis of various polyfunctionalized cyclopenta[b]indoles is described. The synthetic utility of this method has bee

Iron-Catalyzed Electrophilic Amination of Sodium Sulfinates with Anthranils

A practical method for the synthesis of N-(2-carbonylaryl) benzenesulfonamides via an iron-catalyzed electrophilic amination of sodium sulfinates with anthranils is described. This redox-neutral transformation has high atom efficiency and is achieved under simple and mild reaction conditions. A wide range of anthranils and sodium sulfinates were compatible in this transformation. Moreover, the synthetic potential of this methodology was further demonstrated by the synthesis of various useful N-heterocycles and derivatives.

Transition metal-free approach to azafluoranthene scaffolds by aldol condensation/[1+2+3] annulation tandem reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes

A transition metal-free aldol condensation/[1+2+3] annulation reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes has been developed for the general synthesis of azafluoranthenes. This domino reaction enables successive formation of three new bonds and two rings from readily accessible starting materials in a single operation. Furthermore, this methodology can also be utilized to construct chromeno[4,3-c]pyridines and benzo[c][2,6]naphthyridines in moderate yields.

Copper-Catalyzed (4+1) Cascade Annulation of Terminal Alkynes with 2-(Tosylmethyl)anilines: Synthesis of 2,3-Disubstituted Indoles

A novel strategy based on Cu-catalyzed (4+1) cascade annulation of terminal alkynes as one-carbon synthons with 2-(tosylmethyl)anilines has been developed for the expeditious synthesis of 2,3-disubstituted indoles, in which in situ generations of aza-o-quinone methides and alkynyl-copper(I) species are involved. This annulation provides an effective method for the assembly of synthetically and structurally interesting 2,3-disubstituted indoles.

Cascade Skeletal Rearrangement of Gold Carbene Intermediates: Synthesis of Medium-Sized Pyrimidine-Fused Benzolactones

A gold-catalyzed cyclization/cascade skeletal rearrangement of o-cyanophenylalkynones with 3-amino-benzo[d]-isoxazoles has been developed, which provides an approach for synthesizing medium-sized benzolactones. Based on the experimental results, we postul

FUSED-GLUTARIMIDE CRBN LIGANDS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same. The present invention also relates to compounds and methods useful for binding and modulating the activity of cereblon (CRBN), especially for the inhibition of CRBN, and the treatment of CRBN-mediated disorders.

SUBSTITUTED CHROMANES, ANALOGS THEREOF, AND METHODS OF USE AND SYNTHESIS

Disclosed are chromane compounds, analogs thereof, and methods of their synthesis and use. The compounds may be synthesized by methods involving reductive annulations of arylidene malonates with unsaturated electrophiles using photoredox/Lewis acid cooperative catalysis. The compounds may be formulated in a pharmaceutical composition for treating one of the aforementioned diseases or disorders.