[3-(2,6-difluoro-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-acetaldehyde

Base Information

• Chemical Name: [3-(2,6-difluoro-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-acetaldehyde
• CAS No.: 352303-61-8
• Molecular Formula: C₁₄H₁₂F₂N₂O₃
• Molecular Weight: 294.258

Synonyms:[3-(2,6-difluoro-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-acetaldehyde

Chemical Property of [3-(2,6-difluoro-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-acetaldehyde

Chemical Property:

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Technology Process of [3-(2,6-difluoro-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-acetaldehyde

There total 3 articles about [3-(2,6-difluoro-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2,6-difluorobenzyl)-3-allyl-6-methyluracil (352303-60-7) → [3-(2,6-difluoro-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-acetaldehyde (352303-61-8)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1021/jm034041s

Reference yield:

N3-monoallyl-6-methyluracil (59857-37-3) → [3-(2,6-difluoro-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-acetaldehyde (352303-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / Bu₄NF / dimethylformamide; tetrahydrofuran / 48 h / 20 °C

2: OsO₄; aq. NaIO₄ / tetrahydrofuran / 3 h / 20 °C

With sodium periodate; osmium(VIII) oxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm030472z

Reference yield:

2,6-Difluorobenzyl bromide (85118-00-9) → [3-(2,6-difluoro-benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-acetaldehyde (352303-61-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / Bu₄NF / dimethylformamide; tetrahydrofuran / 48 h / 20 °C

2: OsO₄; aq. NaIO₄ / tetrahydrofuran / 3 h / 20 °C

With sodium periodate; osmium(VIII) oxide; tetrabutyl ammonium fluoride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm030472z

upstream raw materials:

1-(2,6-difluorobenzyl)-3-allyl-6-methyluracil

N₃-monoallyl-6-methyluracil

2,6-Difluorobenzyl bromide

Downstream raw materials:

1-(2,6-difluorobenzyl)-3-(2-oxoethyl)-5-bromo-6-methyluracil

1-(2,6-difluorobenzyl)-3-(2-oxoethyl)-5-(3-methoxyphenyl)-6-methyluracil

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