(2R,5S)-2-Methyl-5-((E)-3-oxo-dec-1-enyl)-pyrrolidine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(2R,5S)-2-Methyl-5-((E)-3-oxo-dec-1-enyl)-pyrrolidine-1-carboxylic acid benzyl ester
CAS No.:152231-17-9
Molecular Formula:C₂₃H₃₃NO₃
Molecular Weight:371.52
Hs Code.:

Synonyms:(2R,5S)-2-Methyl-5-((E)-3-oxo-dec-1-enyl)-pyrrolidine-1-carboxylic acid benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,5S)-2-Methyl-5-((E)-3-oxo-dec-1-enyl)-pyrrolidine-1-carboxylic acid benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2R,5S)-2-Methyl-5-((E)-3-oxo-dec-1-enyl)-pyrrolidine-1-carboxylic acid benzyl ester

There total 12 articles about (2R,5S)-2-Methyl-5-((E)-3-oxo-dec-1-enyl)-pyrrolidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 41693-09-8
(2-oxononanylidene)triphenylphosphorane

: 135625-68-2
(2S,5R)-2-Formyl-5-methyl-pyrrolidine-1-carboxylic acid benzyl ester

: 152231-17-9
(2R,5S)-2-Methyl-5-((E)-3-oxo-dec-1-enyl)-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: In toluene; at 80 ℃; for 48h;
DOI:10.1016/0040-4039(93)88073-R

Reference yield:

: 17342-08-4
(S)-5-Hydroxymethyl-4,5-dihydro-3H-pyrrol-2-ol

: 152231-17-9
(2R,5S)-2-Methyl-5-((E)-3-oxo-dec-1-enyl)-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: pyridine

2: CH₂Cl₂

3: Ni(acac)2 / CHCl₃ / Heating

4: 83 percent / 5N HCl / 60 °C

5: NaHB(OAc)3 / toluene

6: 87 percent / NaHCO₃ / H₂O / 48 h / 80 °C

7: (COCl)2, DMSO, NEt₃ / -78 °C

8: 56 percent / toluene / 48 h / 80 °C

With pyridine; hydrogenchloride; bis(acetylacetonate)nickel(II); oxalyl dichloride; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; In dichloromethane; chloroform; water; toluene;
DOI:10.1016/0040-4039(93)88073-R

Reference yield:

: 135649-90-0
(2S,5R)-1-(benzyloxycarbonyl)-2-(hydroxymethyl)-5-methylpyrrolidine

: 152231-17-9
(2R,5S)-2-Methyl-5-((E)-3-oxo-dec-1-enyl)-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: (COCl)2, DMSO, NEt₃ / -78 °C

2: 56 percent / toluene / 48 h / 80 °C

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In toluene;
DOI:10.1016/0040-4039(93)88073-R