((S)-2-Methoxy-1-methyl-ethyl)-[(S)-2-methyl-cyclohex-(Z)-ylidene]-amine

Base Information

• Chemical Name: ((S)-2-Methoxy-1-methyl-ethyl)-[(S)-2-methyl-cyclohex-(Z)-ylidene]-amine
• CAS No.: 640291-60-7
• Molecular Formula: C₁₁H₂₁NO
• Molecular Weight: 183.294
• Mol file: 640291-60-7.mol

Synonyms:((S)-2-Methoxy-1-methyl-ethyl)-[(S)-2-methyl-cyclohex-(Z)-ylidene]-amine

Chemical Property of ((S)-2-Methoxy-1-methyl-ethyl)-[(S)-2-methyl-cyclohex-(Z)-ylidene]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((S)-2-Methoxy-1-methyl-ethyl)-[(S)-2-methyl-cyclohex-(Z)-ylidene]-amine

There total 3 articles about ((S)-2-Methoxy-1-methyl-ethyl)-[(S)-2-methyl-cyclohex-(Z)-ylidene]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cyclohexylidene-((S)-2-methoxy-1-methyl-ethyl)-amine (640291-55-0) + methyl iodide (74-88-4) → ((S)-2-Methoxy-1-methyl-ethyl)-[(R)-2-methyl-cyclohex-(Z)-ylidene]-amine + ((S)-2-Methoxy-1-methyl-ethyl)-[(S)-2-methyl-cyclohex-(Z)-ylidene]-amine (640291-60-7)

Guidance literature:

Cyclohexylidene-((S)-2-methoxy-1-methyl-ethyl)-amine; With lithium diisopropyl amide; In tetrahydrofuran; at -65 ℃;

methyl iodide; In tetrahydrofuran; at -78 ℃; for 0.166667h; Title compound not separated from byproducts;

DOI:10.1021/ja030409z

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → ((S)-2-Methoxy-1-methyl-ethyl)-[(S)-2-methyl-cyclohex-(Z)-ylidene]-amine (640291-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: benzene / Heating

2.1: lithium diisopropylamide / tetrahydrofuran / -65 °C

2.2: tetrahydrofuran / 0.17 h / -78 °C

With lithium diisopropyl amide; In tetrahydrofuran; benzene;

DOI:10.1021/ja030409z

Reference yield:

2-Methylcyclohexanone (583-60-8) + (1S)-2-methoxy-1-methylethylamine (37143-54-7,99636-38-1,123410-24-2,99636-32-5) → ((S)-2-Methoxy-1-methyl-ethyl)-[(R)-2-methyl-cyclohex-(Z)-ylidene]-amine + ((S)-2-Methoxy-1-methyl-ethyl)-[(S)-2-methyl-cyclohex-(Z)-ylidene]-amine (640291-60-7) + ((S)-2-Methoxy-1-methyl-ethyl)-[(R)-2-methyl-cyclohex-(E)-ylidene]-amine + ((S)-2-Methoxy-1-methyl-ethyl)-[(S)-2-methyl-cyclohex-(E)-ylidene]-amine

Guidance literature:

In benzene; Heating;

DOI:10.1021/ja030409z

upstream raw materials:

2-Methylcyclohexanone

(1S)-2-methoxy-1-methylethylamine

Cyclohexylidene-((S)-2-methoxy-1-methyl-ethyl)-amine

methyl iodide