benzyl [(2S)-4-amino-1-({(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}amino)-1,4-dioxobutan-2-yl]carbamate (non-preferred name)

Base Information

Chemical Name:benzyl [(2S)-4-amino-1-({(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}amino)-1,4-dioxobutan-2-yl]carbamate (non-preferred name)
CAS No.:136522-18-4
Molecular Formula:C36H51N5O6
Molecular Weight:649.831
Hs Code.:
Mol file:136522-18-4.mol

benzyl [(2S)-4-amino-1-({(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}amino)-1,4-dioxobutan-2-yl]carbamate (non-preferred name)

Synonyms:Benzenepropanamide,N-(4,5-dihydronaphtho[1,2-d]thiazol-2-yl);2-<3(S)-<amino>-2(R)-hydroxy-4-phenylbutyl>-N-tert-butyldecahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide;2-<3-(phenyl)propanoyl>aminobenzo-4,5-dihydrobenzothiazole;

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Chemical Property of benzyl [(2S)-4-amino-1-({(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}amino)-1,4-dioxobutan-2-yl]carbamate (non-preferred name)

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Boiling Point:935.5°C at 760 mmHg
Flash Point:519.6°C
PSA：174.55000
Density:1.186g/cm³
LogP:6.01320

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of benzyl [(2S)-4-amino-1-({(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}amino)-1,4-dioxobutan-2-yl]carbamate (non-preferred name)

There total 67 articles about benzyl [(2S)-4-amino-1-({(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl]-3-hydroxy-1-phenylbutan-2-yl}amino)-1,4-dioxobutan-2-yl]carbamate (non-preferred name) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 2304-96-3
N-benzyloxycarbonyl-L-asparagine

: 136522-17-3
cis-N-butyldecahydro-2-<2(R)-hydroxy-4-phenyl-3(S)-aminobutyl>-(4aS,8aS)-isoquinoline-3(S)-carboxamide

: 136522-18-4
2-<3(S)-<amino>-2(R)-hydroxy-4-phenylbutyl>-N-tert-butyldecahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide

Guidance literature:: With N-ethylmorpholine;; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; for 64h; Ambient temperature;
DOI:10.1021/jo00092a026

Reference yield:

: 128019-40-9,149510-73-6,136465-81-1,168899-60-3
(3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide

: 136522-18-4
2-<3(S)-<amino>-2(R)-hydroxy-4-phenylbutyl>-N-tert-butyldecahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide / 120 °C

2: 1.) MeNH₂, 2.) HCl

With hydrogenchloride; methylamine; In N,N-dimethyl-formamide;

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 136522-18-4
2-<3(S)-<amino>-2(R)-hydroxy-4-phenylbutyl>-N-tert-butyldecahydro-(4aS,8aS)-isoquinoline-3(S)-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: 70 percent / aq. HCl

2: COCl₂

4: 85 percent / H₂ / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr

5: dimethylformamide / 120 °C

6: 1.) MeNH₂, 2.) HCl

With hydrogenchloride; hydrogen; methylamine; Rh/Al₂O₃; In ethyl acetate; N,N-dimethyl-formamide;