2-[4-(dimethylamino)-3-fluorophenyl]-4,5-dihydro-4-hydroxy-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazole

Base Information

Chemical Name:2-[4-(dimethylamino)-3-fluorophenyl]-4,5-dihydro-4-hydroxy-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazole
CAS No.:177661-62-0
Molecular Formula:C₁₉H₁₉F₄N₃O₃S
Molecular Weight:445.438
Hs Code.:

Synonyms:2-[4-(dimethylamino)-3-fluorophenyl]-4,5-dihydro-4-hydroxy-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazole

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Chemical Property of 2-[4-(dimethylamino)-3-fluorophenyl]-4,5-dihydro-4-hydroxy-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazole

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Technology Process of 2-[4-(dimethylamino)-3-fluorophenyl]-4,5-dihydro-4-hydroxy-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazole

There total 5 articles about 2-[4-(dimethylamino)-3-fluorophenyl]-4,5-dihydro-4-hydroxy-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 431-35-6
3-bromo-1,1,1-trifluoroacetone

: 4-Dimethylamino-3-fluoro-N-(4-methanesulfonyl-phenyl)-benzamidine

: 177661-62-0
2-[4-(dimethylamino)-3-fluorophenyl]-4,5-dihydro-4-hydroxy-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazole

Guidance literature:: With sodium hydrogencarbonate; In isopropyl alcohol; at 75 - 80 ℃; for 20h;
DOI:10.1021/jm9700225

Reference yield:

: 64248-62-0
3,4-Difluorobenzonitrile

: 177661-62-0
2-[4-(dimethylamino)-3-fluorophenyl]-4,5-dihydro-4-hydroxy-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / Ambient temperature

2: trimethylaluminum / 1.) toluene, a) 0 deg C - RT, b) RT, 3.5 h, 2.) toluene, 70 deg C - 75 deg C, 17 h

3: sodium hydrogencarbonate / isopropyl alcohol / 20 h / 75 - 80 °C

With trimethylaluminum; sodium hydrogencarbonate; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm9700225

Reference yield:

: 5470-49-5
4-methanesulfonylphenylamine

: 177661-62-0
2-[4-(dimethylamino)-3-fluorophenyl]-4,5-dihydro-4-hydroxy-1-[4-(methylsulfonyl)phenyl]-4-(trifluoromethyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylaluminum / 1.) toluene, a) 0 deg C - RT, b) RT, 3.5 h, 2.) toluene, 70 deg C - 75 deg C, 17 h

2: sodium hydrogencarbonate / isopropyl alcohol / 20 h / 75 - 80 °C

With trimethylaluminum; sodium hydrogencarbonate; In isopropyl alcohol;
DOI:10.1021/jm9700225