N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me)]-OTce

Base Information

Chemical Name:N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me)]-OTce
CAS No.:270587-97-8
Molecular Formula:C₅₇H₈₁Cl₃N₁₀O₁₇S₆
Molecular Weight:1477.08
Hs Code.:

Synonyms:N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me)]-OTce

Suppliers and Price of N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me)]-OTce

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me)]-OTce

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me)]-OTce

There total 16 articles about N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me)]-OTce which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 270587-93-4
(S)-3-[(S)-2-({(R)-3-(Acetylamino-methylsulfanyl)-2-[(2-amino-acetyl)-methyl-amino]-propionyl}-methyl-amino)-3-methylsulfanyl-propionylsulfanyl]-2-benzyloxycarbonylamino-propionic acid 2,2,2-trichloro-ethyl ester

: 270587-95-6
(S)-3-[(S)-2-({(R)-3-(Acetylamino-methylsulfanyl)-2-[(2-tert-butoxycarbonylamino-acetyl)-methyl-amino]-propionyl}-methyl-amino)-3-methylsulfanyl-propionylsulfanyl]-2-benzyloxycarbonylamino-propionic acid

: 270587-97-8
N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me)]-OTce

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 ℃; for 6h;
DOI:10.1021/ja003602r

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 270587-97-8
N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me)]-OTce

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaOH / tetrahydrofuran; H₂O / 1 h / 25 °C

2.1: pyridine; HOBt; DCC / 24 h / -20 °C

3.1: 99 percent / Ph₃P; 2-mercaptoethanol / tetrahydrofuran; H₂O / 5 h / 50 °C

4.1: HOAt; EDCI / CH₂Cl₂ / 15 h / -20 °C

4.2: 49 percent / CH₂Cl₂ / 4 h

5.1: 100 percent / Zn; 90percent aq. AcOH / 2 h / 0 °C

6.1: 83 percent / HOAt; EDCI / CH₂Cl₂ / 6 h / 0 °C

With pyridine; sodium hydroxide; 1-hydroxy-7-aza-benzotriazole; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dicyclohexyl-carbodiimide; triphenylphosphine; 2-hydroxyethanethiol; zinc; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja003602r

Reference yield:

: 66877-08-5
H-NMe-Cys(Me)-OH

: 270587-97-8
N-Cbz-D-Cys[N-Cbz-D-Cys(N-BOC-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me))-Gly-N-Me-L-Cys(Acm)-N-Me-L-Cys(Me)]-OTce

Guidance literature:: Multi-step reaction with 10 steps

1.1: H₂O / 12 h / 25 °C / pH 8

2.1: 91 percent / benzene; methanol / 0 °C

3.1: 91 percent / HCl / ethyl acetate / 0.5 h / 25 °C

4.1: HOAt; EDCI / CH₂Cl₂ / 0.25 h / 0 °C

4.2: 78 percent / CH₂Cl₂ / 12 h

5.1: 100 percent / HCl / ethyl acetate / 0.5 h / 25 °C

6.1: 68 percent / HOAt; EDCI; NaHCO₃ / CH₂Cl₂ / 12 h / 0 °C

7.1: 100 percent / aq. LiOH / tetrahydrofuran; methanol / 1.5 h / 25 °C

8.1: HOAt; EDCI / CH₂Cl₂ / 15 h / -20 °C

8.2: 49 percent / CH₂Cl₂ / 4 h

9.1: 100 percent / Zn; 90percent aq. AcOH / 2 h / 0 °C

10.1: 83 percent / HOAt; EDCI / CH₂Cl₂ / 6 h / 0 °C

With hydrogenchloride; lithium hydroxide; 1-hydroxy-7-aza-benzotriazole; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; zinc; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; benzene;
DOI:10.1021/ja003602r