(-)-(4S,4'S,5S,5'S)-4,4'-Bis<<(tert-Butyl)dimethylsilyloxy>methyl>-4,4',5,5'-tetrahydro-2,2'-methylene-5,5'-diphenylbis

Base Information

• Chemical Name: (-)-(4S,4'S,5S,5'S)-4,4'-Bis<<(tert-Butyl)dimethylsilyloxy>methyl>-4,4',5,5'-tetrahydro-2,2'-methylene-5,5'-diphenylbis
• CAS No.: 133519-85-4
• Molecular Formula: C₃₃H₅₀N₂O₄Si₂
• Molecular Weight: 594.942
• Mol file: 133519-85-4.mol

Synonyms:(-)-(4S,4'S,5S,5'S)-4,4'-Bis<<(tert-Butyl)dimethylsilyloxy>methyl>-4,4',5,5'-tetrahydro-2,2'-methylene-5,5'-diphenylbis

Chemical Property of (-)-(4S,4'S,5S,5'S)-4,4'-Bis<<(tert-Butyl)dimethylsilyloxy>methyl>-4,4',5,5'-tetrahydro-2,2'-methylene-5,5'-diphenylbis

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(4S,4'S,5S,5'S)-4,4'-Bis<<(tert-Butyl)dimethylsilyloxy>methyl>-4,4',5,5'-tetrahydro-2,2'-methylene-5,5'-diphenylbis

There total 3 articles about (-)-(4S,4'S,5S,5'S)-4,4'-Bis<<(tert-Butyl)dimethylsilyloxy>methyl>-4,4',5,5'-tetrahydro-2,2'-methylene-5,5'-diphenylbis which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis-4,4'-di(methanol) (133463-87-3) + tert-butyldimethylsilyl chloride (18162-48-6) → (-)-(4S,4'S,5S,5'S)-4,4'-Bis<<(tert-Butyl)dimethylsilyloxy>methyl>-4,4',5,5'-tetrahydro-2,2'-methylene-5,5'-diphenylbis (133519-85-4)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 66 ℃; for 29h;

DOI:10.1002/hlca.19910740103

Reference yield:

(1S,2S)-2-amino-1-phenyl-1,3-diol (28143-91-1) → (-)-(4S,4'S,5S,5'S)-4,4'-Bis<<(tert-Butyl)dimethylsilyloxy>methyl>-4,4',5,5'-tetrahydro-2,2'-methylene-5,5'-diphenylbis (133519-85-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / dimethylformamide / 72 h / Ambient temperature

2: 76 percent / imidazole / dimethylformamide / 29 h / 66 °C

With 1H-imidazole; In N,N-dimethyl-formamide;

DOI:10.1002/hlca.19910740103

Reference yield:

Ethyl 3-amino-3-ethoxyprop-2-enimidate dihydrochloride → (-)-(4S,4'S,5S,5'S)-4,4'-Bis<<(tert-Butyl)dimethylsilyloxy>methyl>-4,4',5,5'-tetrahydro-2,2'-methylene-5,5'-diphenylbis (133519-85-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent / dimethylformamide / 72 h / Ambient temperature

2: 76 percent / imidazole / dimethylformamide / 29 h / 66 °C

With 1H-imidazole; In N,N-dimethyl-formamide;

DOI:10.1002/hlca.19910740103

upstream raw materials:

(-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis-4,4'-di(methanol)

tert-butyldimethylsilyl chloride

(1S,2S)-2-amino-1-phenyl-1,3-diol