2-(4-bromophenyl)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-hydroxy-1-phenylbutane

Base Information

Chemical Name:2-(4-bromophenyl)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-hydroxy-1-phenylbutane
CAS No.:81278-54-8
Molecular Formula:C₂₆H₃₀BrNO₂
Molecular Weight:468.434
Hs Code.:

Synonyms:2-(4-bromophenyl)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-hydroxy-1-phenylbutane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-bromophenyl)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-hydroxy-1-phenylbutane

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Technology Process of 2-(4-bromophenyl)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-hydroxy-1-phenylbutane

There total 5 articles about 2-(4-bromophenyl)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-hydroxy-1-phenylbutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.9%

: 2474-07-9
[2-(4-bromophenoxy)ethyl]dimethylamine

: 2-(4-bromophenyl)-1-phenylbutan-1-one

: 81278-54-8
2-(4-bromophenyl)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-hydroxy-1-phenylbutane

Guidance literature:: With n-butyllithium; In tetrahydrofuran; at -58 - 20 ℃; for 8h; Solvent;

Reference yield:

: 67205-73-6
2-(4-bromophenyl)-1-(4-methoxyphenyl)-1-ethanone

: 81278-54-8
2-(4-bromophenyl)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-hydroxy-1-phenylbutane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) THF, RT, 1 h, 2.) THF, 0 deg C, 40 min

2: 96 percent / NaH, ethanethiol / dimethylformamide / 9 h / 90 °C

3: 1.) EtONa / 1.) EtOH, 2.) EtOH, reflux, 12 h

4: 1.) Mg / 1.) Et₂O, RT, 2 h, 2.) Et₂O, RT, 2 h

With sodium ethanolate; sodium hydride; magnesium; ethanethiol; In N,N-dimethyl-formamide;
DOI:10.1021/jo00133a030

Reference yield:

: 81278-40-2
2-(4-bromophenyl)-1-(4-methoxyphenyl)-1-butanone

: 81278-54-8
2-(4-bromophenyl)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-hydroxy-1-phenylbutane

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / NaH, ethanethiol / dimethylformamide / 9 h / 90 °C

2: 1.) EtONa / 1.) EtOH, 2.) EtOH, reflux, 12 h

3: 1.) Mg / 1.) Et₂O, RT, 2 h, 2.) Et₂O, RT, 2 h

With sodium ethanolate; sodium hydride; magnesium; ethanethiol; In N,N-dimethyl-formamide;
DOI:10.1021/jo00133a030