2474-07-9

Basic information

• Product Name: 2-(4-Bromophenoxy)-N,N-dimethylethylamine
• Synonyms: 2-(4-BROMOPHENOXY)-N,N-DIMETHYLETHYLAMINE;[2-(4-BROMO-PHENOXY)-ETHYL]-DIMETHYL-AMINE;4-(2-DIMETHYLAMINOETHOXY)BROMOBENZENE;4-[2-N,N-DIMETHYLETHOXY]PHENYLBROMIDE;4-[2-N,N-DIMETHYLAMINOETHOXY]BROMOBENZENE;2-(4-Bromophenoxy)-N,N-dimethylethylamine 97%;4-[2-N,N-DIMETHYLAMINOETHOXY]PHENYLBROMIDE;2-(N,N-Dimethylamino)ethyl 4-bromophenyl ether
• CAS NO: 2474-07-9
• Molecular Formula: C₁₀H₁₄BrNO
• Molecular Weight: 244.13
• Product Categories: Amines;Aromatics;Intermediates
• Mol File: 2474-07-9.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 286.7 °C at 760 mmHg
• Flash Point: 127.2 °C
• Appearance: /
• Density: 1.309 g/cm³
• Vapor Pressure: 0.0026mmHg at 25°C
• Refractive Index: 1.537
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Soluble in chloroform, dichloromethane.
• PKA: 8.59±0.28(Predicted)
• CAS DataBase Reference: 2-(4-Bromophenoxy)-N,N-dimethylethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Bromophenoxy)-N,N-dimethylethylamine(2474-07-9)
• EPA Substance Registry System: 2-(4-Bromophenoxy)-N,N-dimethylethylamine(2474-07-9)

Safety Data

• Hazard Codes: C
• Statements: 36/37/38-34
• Safety Statements: 26-36/37/39-45-23
• HazardClass: 8
• Hazardous Substances Data: 2474-07-9(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Oil

Uses

An intermediate for the synthesis of Tamoxifen.

InChI:InChI=1/C10H14BrNO/c1-12(2)7-8-13-10-5-3-9(11)4-6-10/h3-6H,7-8H2,1-2H3

Upstream product

• 106-41-2 4-bromo-phenol 
• 107-99-3 2-(dimethylamino)ethyl chloride 
• 591-20-8 3-Bromophenol 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 

Downstream Products

• 131558-80-0 Dimethyl-[2-(4-trimethylsilanylethynyl-phenoxy)-ethyl]-amine 
• 2474-10-4 C₃₀H₄₈Br₂N₂O₂⁽²⁺⁾*2Br^(1-) 
• 103304-52-5 6,7-dihydro-8-phenyl-9-{4-[2-(dimethylamino)ethoxy]phenyl}-5H-benzocycloheptene 
• 81278-52-6 (E,Z)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1-phenyl-2-(3,4,5-tribromophenyl)-1-butene 
• 35258-27-6 {4-[2-(dimethylamino)ethoxy]phenyl}magnesium bromide 
• 97151-11-6 trans-(Z)-1-<4-<2-(dimethylamino)ethoxy>phenyl>-1,2-diphenylethylene 
• 97151-10-5 cis-1,2-diphenyl-1-<4-(2-dimethylaminoethoxy)phenyl>ethylene 
• 1372163-82-0 3-acetoxy-11β-[4-(2-dimethylamino-ethoxy)-phenyl]-estra-1,3,5(10)-triene-17-one 
• 1372163-83-1 11β-[4-(2-methylamino-ethoxy)-phenyl]-estra-1,3,5(10)-triene-3,17β-diol 
• 1372163-84-2 11β-(4-{2-[(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethyl)-methyl-amino]-ethoxy}-phenyl)-estra-1,3,5(10)-triene-3,17β-diol 
• 10540-29-1 tamoxifen 
• 13002-65-8 (E)-tamoxifen 
• 51360-32-8 1-Phenyl-1-phenylethylene 
• 503273-11-8 6-(tert-butyldimethylsilanyloxy)-1-[4-(2-dimethylaminoethoxy)phenyl]-1-(4-methoxymethoxyphenyl)-2-phenylhexan-1-ol 

Relevant articles and documents

Regioselective, Efficient and Sustainable Bromination Process for the Synthesis of the Antimicrobial Agent Bromiphen Bromide

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An atom efficient synthesis of tamoxifen

The direct carbolithiation of diphenylacetylenes and their cross-coupling procedure taking advantage of the intermediate alkenyllithium reagents are presented. By employing our recently discovered highly active palladium nanoparticle based catalyst, we were able to couple an alkenyllithium reagent with a high (Z/E) selectivity (10:1) and good yield to give the breast cancer drug tamoxifen in just 2 steps from commercially available starting materials and with excellent atom economy and reaction mass efficiency.

Pd(OAc)2-Catalyzed Desulfinative Cross-Coupling of Sodium Sulfinates with β-Bromostyrenes: Synthesis of Tamoxifen

A Pd(OAc)2-catalyzed desulfinative cross-coupling of (Z)-β-halostyrenes with sodium sulfinates in the presence of PPh3 and Na2CO3 at reflux in good yields is reported. The stereocontrolled cross-coupling process provides a series of sulfonylmethyl (Z)-stilbenes. A synthesis of tamoxifen was studied.