2-(2,2,4,6,6-Pentamethyl-3-cyclohexenyl)-1-propanal

Base Information

• Chemical Name: 2-(2,2,4,6,6-Pentamethyl-3-cyclohexenyl)-1-propanal
• CAS No.: 99474-98-3
• Molecular Formula: C₁₄H₂₄O
• Molecular Weight: 208.344
• Mol file: 99474-98-3.mol

Synonyms:2-(2,2,4,6,6-Pentamethyl-3-cyclohexenyl)-1-propanal

Chemical Property of 2-(2,2,4,6,6-Pentamethyl-3-cyclohexenyl)-1-propanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,2,4,6,6-Pentamethyl-3-cyclohexenyl)-1-propanal

There total 3 articles about 2-(2,2,4,6,6-Pentamethyl-3-cyclohexenyl)-1-propanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

rac-2-(2,2,4,6,6-Pentamethyl-3-cyclohexenyl)-2-propen-1-ol (99474-97-2) → 2-(2,2,4,6,6-Pentamethyl-3-cyclohexenyl)-1-propanal (99474-98-3)

Guidance literature:

With lithium 2-aminoethylamide; ethylenediamine; at 120 ℃; for 20h;

DOI:10.1039/c39850000812

Reference yield:

tetramethyl-limonene (3,3,5,5-tetramethyl-p-mentha-1,8-diene) (68930-33-6) → 2-(2,2,4,6,6-Pentamethyl-3-cyclohexenyl)-1-propanal (99474-98-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) B₂H₆, 2) 30percent H₂O₂, 3N NaOH / 1) THF, 2h, 2) 1,5h, 50 deg C

2: pyridiniumchlorochromate / CH₂Cl₂ / 2.5 h / Ambient temperature

With sodium hydroxide; dihydrogen peroxide; pyridinium chlorochromate; diborane; In dichloromethane;

Reference yield:

rac-2-(2,2,4,6,6-Pentamethyl-3-cyclohexenyl)-1-propanol (96850-37-2,96850-38-3) → 2-(2,2,4,6,6-Pentamethyl-3-cyclohexenyl)-1-propanal (99474-98-3)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 2.5h; Yield given; Ambient temperature;

upstream raw materials:

rac-2-(2,2,4,6,6-Pentamethyl-3-cyclohexenyl)-1-propanol

rac-2-(2,2,4,6,6-Pentamethyl-3-cyclohexenyl)-2-propen-1-ol

tetramethyl-limonene (3,3,5,5-tetramethyl-p-mentha-1,8-diene)

Refernces

• 1、 Pauluth, Detlef,Hoffmann, H. M. R.. "Terpenes and Terpenoid Compounds, 17. - Preparation of Oxygenated Tetramethylmethenes and Tetramenthylmenthadienes". . p. 756 - 764. Retrieved 2007/10/02.