<4-(1-azi-2,2,2-trifluoroethyl)-2-thienyl>(3-nitro-4-methoxyphenyl)methanone

Base Information

Chemical Name:<4-(1-azi-2,2,2-trifluoroethyl)-2-thienyl>(3-nitro-4-methoxyphenyl)methanone
CAS No.:111690-66-5
Molecular Formula:C₁₄H₈F₃N₃O₄S
Molecular Weight:371.296
Hs Code.:

Synonyms:<4-(1-azi-2,2,2-trifluoroethyl)-2-thienyl>(3-nitro-4-methoxyphenyl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of <4-(1-azi-2,2,2-trifluoroethyl)-2-thienyl>(3-nitro-4-methoxyphenyl)methanone

Chemical Property:

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Technology Process of <4-(1-azi-2,2,2-trifluoroethyl)-2-thienyl>(3-nitro-4-methoxyphenyl)methanone

There total 9 articles about <4-(1-azi-2,2,2-trifluoroethyl)-2-thienyl>(3-nitro-4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111690-72-3
(4-Methoxy-3-nitro-phenyl)-[4-(3-trifluoromethyl-diaziridin-3-yl)-thiophen-2-yl]-methanone

: 111690-66-5
<4-(1-azi-2,2,2-trifluoroethyl)-2-thienyl>(3-nitro-4-methoxyphenyl)methanone

Guidance literature:: With pyridine; tert-butylhypochlorite; In methanol; at -78 ℃; for 0.75h; Yield given;
DOI:10.1021/jo00237a035

Reference yield:

: 58777-65-4
4-Bromothiophene-2-carboxylic acid chloride

: 111690-66-5
<4-(1-azi-2,2,2-trifluoroethyl)-2-thienyl>(3-nitro-4-methoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 9 steps

1: AlCl₃ / CH₂Cl₂ / 1.) 0 deg C, 0.5 h, 2.) RT, 0.5 h

2: p-toluenesulfonic acid / benzene / 89.5 h / Heating

3: 1.) n-BuLi / 1.) ether, hexane, -78 deg C, 55 min, 2.) 20 min

4: 90 percent / 1 N HCl / tetrahydrofuran / 1 h / Heating

5: 78 percent / concd H₂SO₄, concd HNO₃ / CH₂Cl₂ / 1.5 h / 0 °C

6: 42 percent / hydroxylamine hydrochloride, pyridine / ethanol / 3.5 h / Heating

7: 85 percent / pyridine / 4 h / 80 °C

8: 90 percent / NH₃ / tetrahydrofuran / 1.) -78 deg C, 2.) RT, 1 h

9: pyridine, tert-butyl hypochlorite / methanol / 0.75 h / -78 °C

With pyridine; hydrogenchloride; n-butyllithium; aluminium trichloride; tert-butylhypochlorite; sulfuric acid; hydroxylamine hydrochloride; ammonia; nitric acid; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; benzene;
DOI:10.1021/jo00237a035

Reference yield:

: 66938-33-8
(4-bromo-2-thienyl)(4-methoxyphenyl)methanone

: 111690-66-5
<4-(1-azi-2,2,2-trifluoroethyl)-2-thienyl>(3-nitro-4-methoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 8 steps

1: p-toluenesulfonic acid / benzene / 89.5 h / Heating

2: 1.) n-BuLi / 1.) ether, hexane, -78 deg C, 55 min, 2.) 20 min

3: 90 percent / 1 N HCl / tetrahydrofuran / 1 h / Heating

4: 78 percent / concd H₂SO₄, concd HNO₃ / CH₂Cl₂ / 1.5 h / 0 °C

5: 42 percent / hydroxylamine hydrochloride, pyridine / ethanol / 3.5 h / Heating

6: 85 percent / pyridine / 4 h / 80 °C

7: 90 percent / NH₃ / tetrahydrofuran / 1.) -78 deg C, 2.) RT, 1 h

8: pyridine, tert-butyl hypochlorite / methanol / 0.75 h / -78 °C

With pyridine; hydrogenchloride; n-butyllithium; tert-butylhypochlorite; sulfuric acid; hydroxylamine hydrochloride; ammonia; nitric acid; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; ethanol; dichloromethane; benzene;
DOI:10.1021/jo00237a035