4-{2-[5-({[3,5-bis(trifluoromethyl)phenyl]carbamoyl}amino)-2-methylphenoxy]ethyl}piperazine

Base Information

Chemical Name:4-{2-[5-({[3,5-bis(trifluoromethyl)phenyl]carbamoyl}amino)-2-methylphenoxy]ethyl}piperazine
CAS No.:1257510-20-5
Molecular Formula:C₂₂H₂₄F₆N₄O₂
Molecular Weight:490.449
Hs Code.:

Synonyms:4-{2-[5-({[3,5-bis(trifluoromethyl)phenyl]carbamoyl}amino)-2-methylphenoxy]ethyl}piperazine

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Chemical Property of 4-{2-[5-({[3,5-bis(trifluoromethyl)phenyl]carbamoyl}amino)-2-methylphenoxy]ethyl}piperazine

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Technology Process of 4-{2-[5-({[3,5-bis(trifluoromethyl)phenyl]carbamoyl}amino)-2-methylphenoxy]ethyl}piperazine

There total 6 articles about 4-{2-[5-({[3,5-bis(trifluoromethyl)phenyl]carbamoyl}amino)-2-methylphenoxy]ethyl}piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1257423-73-6
benzyl 4-(2-{5-[(1-{[3,5-bis(trifluoromethyl)phenyl]amino}ethenyl)amino]-2-methylphenoxy}ethyl)piperazine-1-carboxylate

: 1257510-20-5
4-{2-[5-({[3,5-bis(trifluoromethyl)phenyl]carbamoyl}amino)-2-methylphenoxy]ethyl}piperazine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h; under 760.051 Torr; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.10.126

Reference yield:

: 1257423-70-3
benzyl 4-[2-(2-methyl-5-nitrophenoxy)ethyl]piperazine-1-carboxylate

: 1257510-20-5
4-{2-[5-({[3,5-bis(trifluoromethyl)phenyl]carbamoyl}amino)-2-methylphenoxy]ethyl}piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: tin(II) chloride hydrate / ethanol / 1.5 h / 90 °C / Inert atmosphere

2: 1,4-dioxane / 55 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr / Inert atmosphere

With tin(II) chloride hydrate; palladium 10% on activated carbon; hydrogen; In 1,4-dioxane; methanol; ethanol;
DOI:10.1016/j.bmcl.2011.10.126

Reference yield:

: C₂₁H₂₇N₃O₃

: 1257510-20-5
4-{2-[5-({[3,5-bis(trifluoromethyl)phenyl]carbamoyl}amino)-2-methylphenoxy]ethyl}piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-dioxane / 55 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; In 1,4-dioxane; methanol;
DOI:10.1016/j.bmcl.2011.10.126