N-[4-(4-(3-trifluoromethylphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

Base Information

Chemical Name:N-[4-(4-(3-trifluoromethylphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine
CAS No.:1369583-91-4
Molecular Formula:C₃₃H₃₆F₃N₃O₂S
Molecular Weight:595.729
Hs Code.:

Synonyms:N-[4-(4-(3-trifluoromethylphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

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Chemical Property of N-[4-(4-(3-trifluoromethylphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

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Technology Process of N-[4-(4-(3-trifluoromethylphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

There total 6 articles about N-[4-(4-(3-trifluoromethylphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.1%

: 1369583-83-4
C₂₂H₂₄ClNO₂S

: 15532-75-9
1-(3-Trifluoromethylphenyl)piperazine

: 1369583-91-4
N-[4-(4-(3-trifluoromethylphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

Guidance literature:: With triethylamine; sodium iodide; In acetonitrile; at 80 ℃; for 4h;

Reference yield:

: 88-15-3,97511-16-5
2-Acetylthiophene

: 1369583-91-4
N-[4-(4-(3-trifluoromethylphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: N,N-dimethyl-formamide / 3 h / 100 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 20 °C / Reflux

3.1: potassium hydroxide / 0.5 h / 20 °C

3.2: 12 h / 90 °C

4.1: sodium hydrogencarbonate / toluene / 10 h / 90 °C

5.1: dimethyl sulfoxide; potassium hydroxide / 6 h / 80 °C

6.1: triethylamine / dichloromethane / 1.5 h / 20 °C

7.1: triethylamine; sodium iodide / acetonitrile / 4 h / 80 °C

With lithium aluminium tetrahydride; sodium hydrogencarbonate; dimethyl sulfoxide; triethylamine; N,N-dimethyl-formamide; sodium iodide; potassium hydroxide; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1049751-94-1
N-methyl-N-ethyloxyacyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

: 1369583-91-4
N-[4-(4-(3-trifluoromethylphenylpiperazinyl)butyryl)]-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propylamine

Guidance literature:: Multi-step reaction with 3 steps

1: dimethyl sulfoxide; potassium hydroxide / 6 h / 80 °C

2: triethylamine / dichloromethane / 1.5 h / 20 °C

3: triethylamine; sodium iodide / acetonitrile / 4 h / 80 °C

With dimethyl sulfoxide; triethylamine; sodium iodide; potassium hydroxide; In dichloromethane; acetonitrile;