2,2,2-trifluoro-N-(4-(1,1,1-trifluorobuta-2,3-dien-2-yl)phenyl)acetamide

Base Information

Chemical Name:2,2,2-trifluoro-N-(4-(1,1,1-trifluorobuta-2,3-dien-2-yl)phenyl)acetamide
CAS No.:1628200-43-0
Molecular Formula:C₁₂H₇F₆NO
Molecular Weight:295.184
Hs Code.:

Synonyms:2,2,2-trifluoro-N-(4-(1,1,1-trifluorobuta-2,3-dien-2-yl)phenyl)acetamide

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Chemical Property of 2,2,2-trifluoro-N-(4-(1,1,1-trifluorobuta-2,3-dien-2-yl)phenyl)acetamide

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Technology Process of 2,2,2-trifluoro-N-(4-(1,1,1-trifluorobuta-2,3-dien-2-yl)phenyl)acetamide

There total 6 articles about 2,2,2-trifluoro-N-(4-(1,1,1-trifluorobuta-2,3-dien-2-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 2,2,2-trifluoro-N-(4-(3-hydroxyprop-1-yn-1-yl)phenyl)acetamide

: phenyl 2-bromo-2,2-difluoroacetate

: 1628200-43-0
2,2,2-trifluoro-N-(4-(1,1,1-trifluorobuta-2,3-dien-2-yl)phenyl)acetamide

Guidance literature:: With potassium fluoride; copper(l) iodide; 1,10-Phenanthroline; bromodifluoroacetic acid; In N,N-dimethyl-formamide; at 50 ℃; for 24h; Inert atmosphere; Sealed tube; Glovebox;
DOI:10.1021/acs.joc.8b03072

Reference yield: 46.0%

: 1628200-54-3
3-[4-(2,2,2-trifluoroacetamido)phenyl]prop-2-yn-1-yl 2-bromo-2,2-difluoroacetate

: 1628200-43-0
2,2,2-trifluoro-N-(4-(1,1,1-trifluorobuta-2,3-dien-2-yl)phenyl)acetamide

Guidance literature:: With potassium fluoride; copper(l) iodide; 1,10-Phenanthroline; sodium 2-bromo-2,2-difluoro-acetate; In N,N-dimethyl-formamide; at 50 ℃; for 14h; Inert atmosphere;
DOI:10.1021/acs.orglett.5b01027

Reference yield:

: 1628200-54-3
3-[4-(2,2,2-trifluoroacetamido)phenyl]prop-2-yn-1-yl 2-bromo-2,2-difluoroacetate

: (2-bromo-2,2-difluoro-acetyl)oxysodium

: 1628200-36-1
C₁₂H₇F₆NO

: 1628200-43-0
2,2,2-trifluoro-N-(4-(1,1,1-trifluorobuta-2,3-dien-2-yl)phenyl)acetamide

Guidance literature:: sodium 2-bromo-2,2-difluoro-acetate; With potassium fluoride; copper(l) iodide; N,N`-dimethylethylenediamine; In N,N-dimethyl-formamide; at 50 ℃; for 0.166667h; Inert atmosphere;

3-[4-(2,2,2-trifluoroacetamido)phenyl]prop-2-yn-1-yl 2-bromo-2,2-difluoroacetate; In N,N-dimethyl-formamide; at 50 ℃; for 14h; Overall yield = 40 %; Overall yield = 24 mg; regioselective reaction; Inert atmosphere;
DOI:10.1055/s-0033-1339128