(6S)-[2-(tert-butyldiphenylsilyl)-ethyl]-(5S)-methyl-tetrahydropyran-(2S)-carboxylic acid methyl ester

Base Information

Chemical Name:(6S)-[2-(tert-butyldiphenylsilyl)-ethyl]-(5S)-methyl-tetrahydropyran-(2S)-carboxylic acid methyl ester
CAS No.:623566-58-5
Molecular Formula:C₂₆H₃₆O₄Si
Molecular Weight:440.655
Hs Code.:

Synonyms:(6S)-[2-(tert-butyldiphenylsilyl)-ethyl]-(5S)-methyl-tetrahydropyran-(2S)-carboxylic acid methyl ester

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Chemical Property of (6S)-[2-(tert-butyldiphenylsilyl)-ethyl]-(5S)-methyl-tetrahydropyran-(2S)-carboxylic acid methyl ester

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Technology Process of (6S)-[2-(tert-butyldiphenylsilyl)-ethyl]-(5S)-methyl-tetrahydropyran-(2S)-carboxylic acid methyl ester

There total 4 articles about (6S)-[2-(tert-butyldiphenylsilyl)-ethyl]-(5S)-methyl-tetrahydropyran-(2S)-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 58479-61-1
tert-butylchlorodiphenylsilane

: 623566-48-3
(6S)-(2-hydroxy-ethyl)-(5S)-methyl-tetrahydropyran-(2S)-carboxylic acid methyl ester

: 623566-58-5
(6S)-[2-(tert-butyldiphenylsilyl)-ethyl]-(5S)-methyl-tetrahydropyran-(2S)-carboxylic acid methyl ester

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 12h;
DOI:10.1021/ol035581m

Reference yield:

: methyl (2R,3S)-(E)-3-(dimethyl(phenyl)silyl)-2-(trimethylsilyloxy)-hex-4-enoate

: 623566-58-5
(6S)-[2-(tert-butyldiphenylsilyl)-ethyl]-(5S)-methyl-tetrahydropyran-(2S)-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / TMSOTf / CH₂Cl₂ / 4 h / -50 °C

2: 99 percent / H₂ / Pd/C / ethyl acetate / 18 h / 20 °C / 760 Torr

3: 76 percent / aq. CH₃CO₃H; Hg(OAc)2 / 1 h / 20 °C

4: 99 percent / imidazole / dimethylformamide / 12 h / 0 - 20 °C

With 1H-imidazole; peracetic acid; trimethylsilyl trifluoromethanesulfonate; mercury(II) diacetate; hydrogen; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol035581m

Reference yield:

: 623566-47-2
(2S,5S,6S)-6-[2-(dimethylphenylsilyl)vinyl]-5-methyl-5,6-dihydro-2H-pyran-2-carboxylic acid methyl ester

: 623566-58-5
(6S)-[2-(tert-butyldiphenylsilyl)-ethyl]-(5S)-methyl-tetrahydropyran-(2S)-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / H₂ / Pd/C / ethyl acetate / 18 h / 20 °C / 760 Torr

2: 76 percent / aq. CH₃CO₃H; Hg(OAc)2 / 1 h / 20 °C

3: 99 percent / imidazole / dimethylformamide / 12 h / 0 - 20 °C

With 1H-imidazole; peracetic acid; mercury(II) diacetate; hydrogen; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ol035581m