623566-47-2Relevant academic research and scientific papers
[4 + 2]-Annulations of chiral organosilanes: Application to the total synthesis of leucascandrolide A
Su, Qibin,Dakin, Les A.,Panek, James S.
, p. 2 - 24 (2007/10/03)
Complete details of an asymmetric synthesis of leucascandrolide A (1) are described. The synthesis highlights the use of two diastereoselective [4 + 2]-annulations for the assembly of the functionalized bispyranyl macrolide 3. An efficient assembly and un
Enantioselective [4 + 2]-Annulation of Chiral Crotylsilanes: Application to the Synthesis of a C1-C22 Fragment of Leucascandrolide A
Dakin, Les A.,Panek, James S.
, p. 3995 - 3998 (2007/10/03)
(Formula presented). The asymmetric synthesis of a C1-C22 fragment (2) of leucascandrolide A is described. Synthetic highlights include the construction of the C9-C22 pyran fragment using a formal [4 + 2]-annulation of a chiral organosilane. A diastereose
