dibenzyl 1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-3,5-dicarboxylate

Base Information

• Chemical Name: dibenzyl 1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-3,5-dicarboxylate
• CAS No.: 888319-96-8
• Molecular Formula: C₄₁H₄₅NO₆
• Molecular Weight: 647.811
• Mol file: 888319-96-8.mol

Synonyms:dibenzyl 1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-3,5-dicarboxylate

Chemical Property of dibenzyl 1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-3,5-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dibenzyl 1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-3,5-dicarboxylate

There total 4 articles about dibenzyl 1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

dibenzyl indole-3,5-dicarboxylate (888319-95-7) + 2-[(4-octylphenoxy)methyl]oxirane (4223-17-0) → dibenzyl 1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-3,5-dicarboxylate (888319-96-8)

Guidance literature:

dibenzyl indole-3,5-dicarboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃;

2-[(4-octylphenoxy)methyl]oxirane; In N,N-dimethyl-formamide; at 100 ℃; for 40h;

DOI:10.1021/jm051243a

Reference yield:

methyl 3‐formyl‐1H‐indole‐5‐carboxylate (197506-83-5) → dibenzyl 1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-3,5-dicarboxylate (888319-96-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 29 percent / MnO₂; NaCN / 48 h / 20 °C

2.1: KH / 0.25 h / 20 °C

2.2: 50 percent / 5 h / 100 °C

3.1: NaH / dimethylformamide / 20 °C

3.2: 27 percent / dimethylformamide / 40 h / 100 °C

With manganese(IV) oxide; sodium cyanide; potassium hydride; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jm051243a

Reference yield:

dimethyl 1H-indole-3,5-dicarboxylate (888319-94-6) → dibenzyl 1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-3,5-dicarboxylate (888319-96-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: KH / 0.25 h / 20 °C

1.2: 50 percent / 5 h / 100 °C

2.1: NaH / dimethylformamide / 20 °C

2.2: 27 percent / dimethylformamide / 40 h / 100 °C

With potassium hydride; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jm051243a

upstream raw materials:

dibenzyl indole-3,5-dicarboxylate

2-[(4-octylphenoxy)methyl]oxirane

methyl 3‐formyl‐1H‐indole‐5‐carboxylate

dimethyl 1H-indole-3,5-dicarboxylate

Downstream raw materials:

dibenzyl 1-[3-(4-octylphenoxy)-2-oxopropyl]indole-3,5-dicarboxylate