4223-17-0

Basic information

• Product Name: [(p-octylphenoxy)methyl]oxirane
• Synonyms: [(p-octylphenoxy)methyl]oxirane;[(4-Octylphenoxy)methyl]oxirane;4-Octylphenylglycidyl ether;Einecs 224-174-4
• CAS NO: 4223-17-0
• Molecular Formula: C₁₇H₂₆O₂
• Molecular Weight: 262.38714
• EINECS: 224-174-4
• Mol File: 4223-17-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 368.1°Cat760mmHg
• Flash Point: 133.1°C
• Appearance: /
• Density: 0.987g/cm³
• Vapor Pressure: 2.76E-05mmHg at 25°C
• Refractive Index: 1.507
• CAS DataBase Reference: [(p-octylphenoxy)methyl]oxirane(CAS DataBase Reference)
• NIST Chemistry Reference: [(p-octylphenoxy)methyl]oxirane(4223-17-0)
• EPA Substance Registry System: [(p-octylphenoxy)methyl]oxirane(4223-17-0)

Safety Data

• Hazardous Substances Data: 4223-17-0(Hazardous Substances Data)

Usage

General Description

[(p-octylphenoxy)methyl]oxirane, also known as Octylphenoxypolyethoxyethanol and OPME, is a chemical compound commonly used as a surfactant and emulsifier in various industrial and consumer products. It is a clear, colorless liquid with a mild odor and is soluble in water and some organic solvents. OPME is widely used in the manufacture of cleaning products, household detergents, and personal care items such as shampoos and liquid soaps. Its emulsifying properties make it a popular choice for formulating oil-in-water emulsions, and it also acts as a wetting agent, helping to reduce surface tension and improve the spreading and absorption of liquids. However, there have been concerns about its potential environmental and health impacts, particularly on aquatic organisms and human health, leading to increased scrutiny and regulation in some regions.

InChI:InChI=1/C17H26O2/c1-2-3-4-5-6-7-8-15-9-11-16(12-10-15)18-13-17-14-19-17/h9-12,17H,2-8,13-14H2,1H3

Upstream product

• 1806-26-4 p-Octylphenol 
• 106-89-8 epichlorohydrin 

Downstream Products

• 741606-24-6 1-(5-methylindol-1-yl)-3-(4-octylphenoxy)propan-2-ol 
• 741606-25-7 1-(5-chloroindol-1-yl)-3-(4-octylphenoxy)propan-2-ol 
• 741606-29-1 1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-5-carboxylic acid methyl ester 
• 741606-02-0 [1-bromo-3-(4-octylphenoxy)propan-2-yl]acetate 
• 741606-44-0 1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-5-carboxamide 
• 741606-14-4 1-[2-hydroxy-3-(4-octylphenoxy)propyl]indole-3-carboxylic acid tert-butyl ester 
• 741606-15-5 1-[3-(4-octylphenoxy)-2-oxo-propyl]indole-3-carboxylic acid tert-butyl ester 
• 741606-21-3 tert-butyl 1-[3-(4-octylphenoxy)-2-oxopropyl]indole-4-carboxylate 
• 741606-23-5 1-[3-(4-octylphenoxy)-2-oxo-propyl]indole-6-carboxylic acid tert-butyl ester 
• 741606-18-8 tert-butyl 1-[3-(4-octylphenoxy)-2-oxopropyl]indole-5-carboxylate 
• 741606-12-2 tert-butyl 1-[3-(4-octylphenoxy)-2-oxopropyl]indole-2-carboxylate 

Relevant articles and documents

Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2α

The synthesis and structure-activity relationship study of a series of 1-indol-1-yl-3-phenoxypropan-2-one inhibitors of cytosolic phospholipase A 2α. (cPLA2α) are described. The compounds were evaluated in a vesicle assay with isolated cPLA2α and in cellular assays with intact human platelets. Systematic variation led to 3-methylhydrogen 1-[3-(4-decyloxyphenoxy)-2-oxopropyl]indole-3,5-dicarboxylate (57), which revealed the highest activity against the isolated enzyme. With an IC50 value of 4.3 nM in this assay, it is one of the most potent in vitro cPLA2α inhibitors known today.