1-(methoxy(phenyl)methyl)-5-phenyl-6-(4-(trifluoromethyl)phenyl)pyrazolo[5,1-a]isoquinoline

Base Information

Chemical Name:1-(methoxy(phenyl)methyl)-5-phenyl-6-(4-(trifluoromethyl)phenyl)pyrazolo[5,1-a]isoquinoline
CAS No.:1313200-02-0
Molecular Formula:C₃₂H₂₃F₃N₂O
Molecular Weight:508.543
Hs Code.:

Synonyms:1-(methoxy(phenyl)methyl)-5-phenyl-6-(4-(trifluoromethyl)phenyl)pyrazolo[5,1-a]isoquinoline

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Chemical Property of 1-(methoxy(phenyl)methyl)-5-phenyl-6-(4-(trifluoromethyl)phenyl)pyrazolo[5,1-a]isoquinoline

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Technology Process of 1-(methoxy(phenyl)methyl)-5-phenyl-6-(4-(trifluoromethyl)phenyl)pyrazolo[5,1-a]isoquinoline

There total 3 articles about 1-(methoxy(phenyl)methyl)-5-phenyl-6-(4-(trifluoromethyl)phenyl)pyrazolo[5,1-a]isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1313199-73-3
6-bromo-1-(methoxy(phenyl)methyl)-5-phenylpyrazolo[5,1-a]isoquinoline

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1313200-02-0
1-(methoxy(phenyl)methyl)-5-phenyl-6-(4-(trifluoromethyl)phenyl)pyrazolo[5,1-a]isoquinoline

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; In water; N,N-dimethyl-formamide; at 50 ℃; Inert atmosphere;
DOI:10.1055/s-0030-1259704

Reference yield:

: 1112200-32-4
C₂₂H₁₇BrN₂O₂S

: 1313200-02-0
1-(methoxy(phenyl)methyl)-5-phenyl-6-(4-(trifluoromethyl)phenyl)pyrazolo[5,1-a]isoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrachloromethane / 24 h / 50 °C

2: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / water; N,N-dimethyl-formamide / 50 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrachloromethane; water; N,N-dimethyl-formamide; 2: Suzuki-Miyaura coupling;
DOI:10.1055/s-0030-1259704

Reference yield:

: 75586-32-2
2-phenylethynylbenzaldehyde p-toluenesulphonylhydrazone

: 1313200-02-0
1-(methoxy(phenyl)methyl)-5-phenyl-6-(4-(trifluoromethyl)phenyl)pyrazolo[5,1-a]isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: bromine / dichloromethane / 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrachloromethane / 24 h / 50 °C

3: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / water; N,N-dimethyl-formamide / 50 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; bromine; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; 3: Suzuki-Miyaura coupling;
DOI:10.1055/s-0030-1259704