75586-32-2

Upstream product

• 6630-33-7 ortho-bromobenzaldehyde 
• 536-74-3 phenylacetylene 
• 21375-88-2 1-bromo-2-(phenylethenyl)benzene 
• 59046-72-9 o-(phenylethynyl)benzaldehyde 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 

Downstream Products

• 1176334-72-7 diethyl (3-phenylisoquinolin-1-yl)phosphonate 
• 1176334-73-8 diethyl 2-(4-methylphenylsulfonamido)-3-phenyl-1,2-dihydroisoquinolin-1-ylphosphonate 
• 1174271-14-7 2,5-diphenyl-pyrazolo[5,1-a]isoquinoline 
• 1174271-15-8 2-(4-methoxyphenyl)-5-phenyl-pyrazolo[5,1-a]isoquinoline 
• 1112200-37-9 C₂₂H₁₇IN₂O₂S 
• 1112200-32-4 C₂₂H₁₇BrN₂O₂S 
• 1198746-30-3 1-(indol-3-yl)-2-amino-3-phenylisoquinolinium triflate 
• 1198746-36-9 1-(5-bromoindol-3-yl)-2-amino-3-phenylisoquinolinium triflate 
• 1198746-34-7 1-(6-methoxyindol-3-yl)-2-amino-3-phenylisoquinolinium triflate 
• 1198746-32-5 1-(4-methoxyindol-3-yl)-2-amino-3-phenylisoquinolinium triflate 
• 1221497-62-6 1-ethyl-5-phenyl-pyrazolo[5,1-a]isoquinoline 
• 1221497-73-9 6-phenyl-10,11-dihydro-9H-cyclopenta[3,4]pyrazolo[5,1-a]isoquinoline 
• 1200799-01-4 C₂₁H₁₅IN₂O₄ 
• 1262639-23-5 1-methyl-5-phenyl-pyrazolo[5,1-a]isoquinoline 

Relevant academic research and scientific papers

Catalytic Diazosulfonylation of Enynals toward Diazoindenes via Oxidative Radical-Triggered 5-exo-trig Carbocyclizations

Catalytic diazosulfonylation of enynals with arylsulfonyl hydrazides has been established by using tert-butyl hydroperoxide (TBHP) as the oxidant with tetrabutylammonium iodide (TBAI) under a convenient system. The reaction occurred through oxidative radical-triggered 5-exo-trig carbocyclization cascading to afford sulfonylated diazoindenes regioselectively. The new diazosulfonylation reaction features a broad substrate scope, readily accessible starting materials, and a simple one-pot process.

Synthesis of organoselenyl isoquinolinium imidesviairon(iii) chloride-mediated tandem cyclization/selenation ofN′-(2-alkynylbenzylidene)hydrazides and diselenides

This report describes the synthesis of organoselenyl isoquinolinium imides through a tandem cyclization betweenN′-(2-alkynylbenzylidene)hydrazides and diselenides. The reaction was carried out at room temperature under an ambient atmosphere using cheap iron(iii) chloride as the metallic source. The strategy shows good tolerance to a broad range ofN′-(2-alkynylbenzylidene)hydrazides and diselenides, and forms C-N and C-Se bonds in one step. The obtained product is further transformed into a bioactiveH-pyrazolo[5,1-a]isoquinoline skeleton easilyviaa silver catalyzed [3 + 2] cycloaddition.

HETEROCYCLIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE COMPRISING SAME

The present specification relates to a heterocyclic compound represented by Chemical Formula 1, and an organic light emitting device comprising the same.

Silver(I)- and Base-Mediated formal [4+3] Cycloaddition of in Situ generated 1,2-Diaza-1,3-dienes with C,N-Cyclic Azomethine Imines: An Efficient Protocol for the Synthesis of Tetrazepine Derivatives

A silver(I)- and base-mediated formal [4+3] cycloaddition reaction of in situ generated 1,2-diaza-1,3-dienes with in situ formed C,N-cyclic azomethine imines has been developed. This protocol provided an efficient method for the synthesis of biologically important 1,2,4,5-tetrazepine derivatives with a wild substrate scope and excellent functional group tolerance in moderate to excellent yields. (Figure presented.).

Pyrazoloisoquinoline compound and synthesis method thereof

The invention discloses a pyrazoleoisoquinoline compound and a synthesis method thereof. The pyrazoleoisoquinoline compound is represented by a formula I, wherein the R1 represents hydrogen, halogen atoms and alkyl or alkoxy or amino, and the R2 represents hydrogen, halogen atoms and alkyl or alkoxy or amino. The target product is synthesized through four-step reaction, the synthesis method is simple and rapid, the target compound is higher in yield, and a necessary foundation is provided for further research on the compound represented by the formula I or related compounds. In addition, the intermediate provided in the synthesis method is simple in structure and easy to obtain and provides convenience for the preparation of the target compound.

Tetra-substituted pyrazol isoquinoline compound and synthetic method thereof

The invention discloses a tetra-substituted pyrazol isoquinoline compound and a synthetic method thereof. The tetra-substituted pyrazol isoquinoline compound is shown as the formula I, wherein R1 is hydrogen, chlorine atoms, alkyl, alkoxy or amino, and R2 is hydrogen, chlorine atoms, alkyl, alkoxy or amino. A target product is synthesized by virtue of four-step reaction, the synthetic method is simple and rapid, the yield of the target compound is relatively high, and necessary foundation is provided for further researching the compound of formula I and relevant compounds. A midbody provided by the invention is simple in structure and easily available, so that convenience is brought to the preparation of the target compound.

Aryne [3 + 2] cycloaddition with N-sulfonylpyridinium imides and in situ generated N-sulfonylisoquinolinium imides: A potential route to pyrido[1,2-b]indazoles and indazolo[3,2-a]isoquinolines

The aryne [3 + 2] cycloaddition process with pyridinium imides breaks the aromaticity of the pyridine ring. By equipping the imide nitrogen with a sulfonyl group, the intermediate readily eliminates a sulfinate anion to restore the aromaticity, leading to the formation of pyrido[1,2-b]indazoles. The scope and limitation of this reaction are discussed. As an extension of this chemistry, N-tosylisoquinolinium imides, generated in situ from N′-(2-alkynylbenzylidene)-tosylhydrazides via an AgOTf-catalyzed 6-endo-dig electrophilic cyclization, readily undergo aryne [3 + 2] cycloaddition to afford indazolo[3,2-a]-isoquinolines in the same pot, offering a highly efficient route to these potential anticancer agents.

C(sp)-C(sp3) bond formation through cu-catalyzed cross-coupling of N -tosylhydrazones and trialkylsilylethynes

Copper-catalyzed cross-coupling of N-tosylhydrazones with trialkylsilylethynes leads to the formation of C(sp)-C(sp3) bonds. Cu carbene migratory insertion is proposed to play the key role in this transformation.

Generation of diverse 1-(isoquinolin-1-yl)guanidines via a sequential multi-component/cross-coupling reaction

A multi-component reaction of 2-alkynylbenzaldehyde, 4- methylbenzenesulfonohydrazide, carbodiimide, and bromine is reported, which generates 1-(4-bromoisoquinolin-1-yl)guanidines in good yields under mild conditions. The products could be further elaborated via a palladium-catalyzed Suzuki-Miyaura coupling reaction, leading to the diverse 1-(isoquinolin-1-yl) guanidines.

Synthesis of H-pyrazolo[5,1-a]isoquinolines via copper(II)-catalyzed oxidation of an aliphatic C-H bond of tertiary amine in air

A multicomponent reaction of 2-alkynylbenzaldehyde, sulfonohydrazide, and tertiary amine is discovered, which generates the unexpected H-pyrazolo[5,1-a]isoquinolines in good yields under mild conditions. In the reaction process, silver(I)-catalyzed intramolecular cyclization and copper(II)-catalyzed oxidation of an aliphatic C-H bond of tertiary amine in air are involved.