prop-2-yn-1-yl 2-amino-6-(3-(2-chloroacetamido)phenyl)-4-(2-oxo-2-(prop-2-yn-1-yloxy)ethyl)-4H-chromene-3-carboxylate

Base Information

Chemical Name:prop-2-yn-1-yl 2-amino-6-(3-(2-chloroacetamido)phenyl)-4-(2-oxo-2-(prop-2-yn-1-yloxy)ethyl)-4H-chromene-3-carboxylate
CAS No.:1379536-35-2
Molecular Formula:C₂₆H₂₁ClN₂O₆
Molecular Weight:492.916
Hs Code.:

Synonyms:prop-2-yn-1-yl 2-amino-6-(3-(2-chloroacetamido)phenyl)-4-(2-oxo-2-(prop-2-yn-1-yloxy)ethyl)-4H-chromene-3-carboxylate

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Chemical Property of prop-2-yn-1-yl 2-amino-6-(3-(2-chloroacetamido)phenyl)-4-(2-oxo-2-(prop-2-yn-1-yloxy)ethyl)-4H-chromene-3-carboxylate

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Technology Process of prop-2-yn-1-yl 2-amino-6-(3-(2-chloroacetamido)phenyl)-4-(2-oxo-2-(prop-2-yn-1-yloxy)ethyl)-4H-chromene-3-carboxylate

There total 4 articles about prop-2-yn-1-yl 2-amino-6-(3-(2-chloroacetamido)phenyl)-4-(2-oxo-2-(prop-2-yn-1-yloxy)ethyl)-4H-chromene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1379536-23-8
prop-2-yn-1-yl 2-amino-6-(3-aminophenyl)-4-(2-oxo-2-(prop-2-yn-1-yloxy)ethyl)-4H-chromene-3-carboxylate

: 79-04-9
chloroacetyl chloride

: 1379536-35-2
prop-2-yn-1-yl 2-amino-6-(3-(2-chloroacetamido)phenyl)-4-(2-oxo-2-(prop-2-yn-1-yloxy)ethyl)-4H-chromene-3-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/jm300515q

Reference yield:

: 19063-55-9
6-bromo-2H-chromen-2-one

: 1379536-35-2
prop-2-yn-1-yl 2-amino-6-(3-(2-chloroacetamido)phenyl)-4-(2-oxo-2-(prop-2-yn-1-yloxy)ethyl)-4H-chromene-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; toluene / 80 - 90 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; ammonium formate / methanol / 6 h / 20 °C / Inert atmosphere

3.1: sodium / 0.5 h / 20 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; ammonium formate; sodium; potassium carbonate; triethylamine; In methanol; dichloromethane; water; toluene; 1.1: Suzuki coupling;
DOI:10.1021/jm300515q

Reference yield:

: 1761-61-1
5-bromosalicyclaldehyde

: 1379536-35-2
prop-2-yn-1-yl 2-amino-6-(3-(2-chloroacetamido)phenyl)-4-(2-oxo-2-(prop-2-yn-1-yloxy)ethyl)-4H-chromene-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / dichloromethane / 4 h / 80 °C

1.2: 1 h / 60 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; toluene / 80 - 90 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; ammonium formate / methanol / 6 h / 20 °C / Inert atmosphere

4.1: sodium / 0.5 h / 20 °C / Inert atmosphere

4.2: 20 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; ammonium formate; sodium; potassium carbonate; triethylamine; trichlorophosphate; In methanol; dichloromethane; water; toluene; 2.1: Suzuki coupling;
DOI:10.1021/jm300515q